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Anti and proinflammatory biomarkers in normotensive and hypertensive women: Effects of physical exercise and L-arginine Supplementation

Grant number: 11/11457-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2011
Effective date (End): February 28, 2013
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Angelina Zanesco
Grantee:Guilherme Morais Puga
Home Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil


The nitric oxide (NO) regulates the vascular tone homeostasis, inhibits the platelets aggregations and the vascular control, in the cardiovascular system, through the endothelial nitric oxide synhtases (eNOS) actions. The L-arginine is a substrate for NO production and this amino acids bioavailability regulate the NO formation. Based on this relationship, some studies investigated the effects of L-arginine infusion and supplementation on cardiovascular system, especially on the endothelial dysfunction improvement. Those possible positive effects are similar to that produced from exercise, and together these interventions can produce additive effects. Thus the purpose of this study will be to verify the effects of L-arginine supplementation on the anti and proinflammatory and hemodynamic responses in women with and without hypertension. Thirty women older than 50 yr (fifteen with hypertension and fifteen without hypertension) will take part of this study. All the participants will perform and aerobic evaluation test on treadmill and the anthropometrics characteristics will be measured. After theses measures all the participants will perform four experimental sections in random order and separated by at least 72 hours between them. The participants will receive 9 g of L-arginine or placebo, or nothing in the control day. One hour after this intervention, all the participants will perform 30 minutes of aerobic exercise on treadmill at the lactate threshold intensity, but not during the control day that will not have nor supplementation nor exercise performance. Blood sample will be collected immediately after, and 45 and 90 minutes after the end of the exercise. The blood pressure will be measured through 24 hour after the end of the exercise. Anti and proinflammatory biomarkers, lipid levels, nitrite/nitrate, oxidative stress markers, ADMA, glucose and lactate concentrations will be measured from the plasma and/or serum. All the results will be analyzed based on the blood concentration responses and time relationships in the area under the curve.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PUGA, GUILHERME M.; NOVAIS, IANE DE P.; KATSANOS, CHRISTOS S.; ZANESCO, ANGELINA. Combined effects of aerobic exercise and L-arginine ingestion on blood pressure in normotensive postmenopausal women: A crossover study. Life Sciences, v. 151, p. 323-329, APR 15 2016. Web of Science Citations: 3.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PUGA, Guilherme Morais. Efeitos agudos da suplementação de l-arginina e do exercício físico aeróbio nas respostas hemodinâmicas e endócrino-metabólicas em mulheres após a menopausa. 2013. 111 f. Doctoral Thesis - Universidade Estadual Paulista "Júlio de Mesquita Filho". Instituto de Biociências..

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