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Application of new organometallic reagents in synthesis of bioactive substance

Grant number: 11/12589-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): February 01, 2012
Effective date (End): January 31, 2015
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Giuliano Cesar Clososki
Grantee:João Henrique Carvalho Batista
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:08/04762-4 - New synthetic methods for the preparation of bioactive compounds, AP.JP


The objective of this project is the development of organometallic reagents for biological active molecules synthesis. In the first part of the work a number of bases such as TMPLi, TMPMgCl.LiCl, TMPZnCl.LiCl e TMP2Mg.2LiCl will be prepared and used in the functionalization of dioxinones. Aiming to develop more stable and selective bases, in the second part of the work some new bases derived from cis-dimethylpiperidyne and tert-butylamine will be prepared and studied. The development of the project will contribute with the synthesis of some bioactive molecules in the group such as the caramboxina and talnetant.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BOZZINI, LEANDRO A.; BATISTA, JOAO H. C.; DE MELLO, MURILO B. M.; VESSECCHI, RICARDO; CLOSOSKI, GIULIANO C. Selective functionalization of cyano-phenyl-2-oxazolines using TMPMgCl center dot LiCl. Tetrahedron Letters, v. 58, n. 44, p. 4186-4190, NOV 1 2017. Web of Science Citations: 9.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BATISTA, João Henrique Carvalho. Directed functionalization of 2-oxazolines and dioxinones using mixed magnesium-lithium bases. 2015. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto Ribeirão Preto.

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