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Characterization of the inflammatory responses in human papillomavirus associated cervical lesions

Grant number: 11/20499-4
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): March 01, 2012
Effective date (End): May 31, 2016
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal Investigator:Ana Paula Lepique
Grantee:Karla Lucía Alvarez Fernández
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Cervical cancer is a common type of cancer among women in developing countries. The main etiological factor for this type of cancer is the persistent infection with a high oncogenic risk Human Papillomavirus. However, although these viruses display several immune evasion mechanisms, most infected women are naturally capable of eliminating the infection, even when precursor lesions have developed. A fraction of the infected women, however, display persistent HPV infections that may progress to high grade lesions or invasive cancer. Data in the literature indicate that in cancer patients there is an increase in the number of HPV specific regulatory T cells. On the other hand, other groups show that there is a positive correlation between lesion grade and number of inflammatory infiltrating cells in the cervix. The objective of this project is to characterize qualitative and functionally the inflammatory responses in the HPV associated cervical lesions. To that end, we propose a prospective study where low and high grade cervical lesion samples will be collected from patients together with a blood sample of the same patient. In the biopsies we will identify, quantify and determine the activity of inflammatory cells. In the blood samples we will study monocyte and antigen presenting cells phenotype and function. Data obtained in this project is will be extremely relevant in terms of lesion progression and also therapeutic strategies, once interference in the inflammatory processes taking place during lesion progression may alter presentation of viral antigens and anti-HPV immune responses. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROSSETTI, RENATA A. M.; DA SILVA-JUNIOR, ILDEFONSO A.; R RODRIGUEZ, GRETEL; ALVAREZ, KARLA L. F.; STONE, SIMONE C.; CIPELLI, MARCELLA; SILVEIRA, CAIO R. F.; BELDI, MARIANA CARMEZIM; MOTA, GIANA R.; MARGARIDO, PAULO F. R.; et al. Local and Systemic STAT3 and p65 NF-KappaB Expression as Progression Markers and Functional Targets for Patients With Cervical Cancer. FRONTIERS IN ONCOLOGY, v. 10, . (14/19326-6, 13/26856-9, 16/16149-1, 18/16989-5, 11/20499-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FERNÁNDEZ, Karla Lucía Alvarez. Characterization of the inflammatory infiltrate in cervical cancer and precursor lesions.. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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