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Role of LH during induced luteolysis and characterization of luteal sensitivity to PGF2alpha during estrus cycle and treatment with IFNt

Grant number: 11/20449-7
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): February 01, 2012
Effective date (End): September 30, 2014
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Reproduction
Principal Investigator:João Carlos Pinheiro Ferreira
Grantee:Eduardo Trevisol
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated scholarship(s):13/17801-6 - Evaluation of the hormonal and molecular pathways involved in maintaining the corpus luteum of pregnancy in lactating dairy cows, BE.EP.DR


The PhD project aims to enhance studies on luteal regression in cattle. For this three researches will be conducted. Experiment 1: aim to evaluate LH effects on the rescue of P4 secretion after challenge with cloprostenol sodium at D7 of estrous cycle (D0=estrous). Caracu cows on D7 will bee submitted to the following treatments: Group 1 (G1): saline, G2: saline associate to GnRH antagonist (acyline), G3: 1/6 of cloprostenol conventional dose, G4: 1/6 of cloprostenol conventional dose after acycline administration, G5: cloprostenol conventional dose. From 12 to 20 hours after treatment blood samples will be collected every 1 hour to LH assays. Experiment 2: aim to evaluate CL sensibility to PGF2 subdoses at initial (D7) and medium (D12) phases. Caracu cows will be placed in the following groups: G1: saline D7, G2: saline D12, G3: 1/6 of cloprostenol conventional at D7, G4: 1/6 of cloprostenol conventional at D12. Experiment 3: aim to evaluate CL sensibility after intra uterine exposure of bovine Interferon Tau (IFNÄ). Caracu cows will be placed in two groups: G1: intra uterine infusions of IFNÄ from D9 to D12 following by PGF2± challenge at D12. G2 (control group): PGF2± challenge at D12. In all experiments immediately after treatments (0hour) and after this every 8 hours until 48hours (M48) the animals will be submitted to transrectal ultrassonographic evaluation at mod B (luteal volume) and Power Doppler (luteal blood perfusion). Blood samples will be collected for P4 assays. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TREVISOL, EDUARDO; FERREIRA, JAIR CAMARGO; ACKERMANN, CAMILA LOUISE; DESTRO, FLAVIA CAROLINE; MARQUES FILHO, WOLFF CAMARGO; CARMAGOS, ALINE SOUZA; BIEHL, MARCOS VINICIUS; DO AMARAL, JACKSON BARROS; DE FIGUEIREDO PANTOJA, JOSE CARLOS; SARTORI, ROBERTO; et al. Luteal changes after treatment with sub-luteolytic doses of prostaglandin (cloprostenol sodium) in cattle. Animal Reproduction Science, v. 153, p. 8-12, . (12/18297-7, 11/20449-7)
TREVISOL, E.; MOGOLLON GARCIA, H. D.; ACKERMANN, C. L.; LACERDA, W.; PIRES, R. M. L.; LAUFER-AMORIN, R.; CARVALHO, R. F.; FRANCHI, F. F.; CASTILHO, A. C. S.; RIZZOTO, G.; et al. Partial luteolysis during early diestrus in cattle downregulates VEGFA expression and reduces large luteal cell and corpus luteum sizes and plasma progesterone concentration. Theriogenology, v. 158, p. 188-195, . (11/20449-7, 12/18297-7)
MOGOLLON, H. D. G.; FERRAZZA, R. A.; VALLEJO, V. H.; DESTRO, F. C.; OCHOA, J. C.; NOGUEIRA, C.; CARVALHO, R. F.; MORAES, L. N.; RIZZOTO, G.; SARTORI, R.; et al. Short communication: Heat stress does not affect induced luteolysis in Holstein cows. JOURNAL OF DAIRY SCIENCE, v. 103, n. 6, p. 5629-5633, . (12/18297-7, 11/20449-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
TREVISOL, Eduardo. Functional and morphological changes in bovine corpus luteum during full and parcial luteolysis and luteal feature to low dose of cloroprostenol sodium during estrous cycle. 2014. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária e Zootecnia. Botucatu Botucatu.

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