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Pathogeny assessment of Salmonella enterica subspecies enterica serovar Gallinarum biovar Gallinarum strains with genes responsible for expression of assets flagella

Grant number: 11/14763-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): December 31, 2013
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal Investigator:Angelo Berchieri Junior
Grantee:Priscila Diniz Lopes
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil


Salmonella spp. are Gram-negative microorganisms. Currently, there are over 2500 serovars of Salmonella. Salmonella enterica subspecies enterica serovar Gallinarum biovar Gallinarum (SG) and biovar Pullorum (SP) are two non-flagellated biovars causative of two different avian systemic diseases, fowl typhoid and pullorum disease, respectively. It is believed that the absence of flagella induces low production of pro-inflammatory interleukins, reducing inflammatory responses in intestinal epithelium and favoring systemic infection. Flagellin, the main flagellar protein, has the capacity of stimulating the TLR-5 and consequently to trigger the production of pro-inflammatory cytokines and chemokines which induce a rapid inflammation on the intestinal mucosa, reducing the severity of systemic infection. In a previous study carried out by this research group (FAPESP: 2007/59233-3), a SG mutant strain capable of expressing flagella (SG Fla+) was produced. SG Fla+ is less pathogenic and can also induce inflammation in the intestinal mucosa of birds. However, it was noticed that SG Fla+, although capable of expressing flagella, trends to stop its production after two or more consecutive passages in vitro, becoming phenotypically aflagellated (SG Fla-). This study aims to assess the importance of the flagella in the pathogenesis of SG, phenotypes SG Fla+ and SG Fla- comparing to the SG wild type strain.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOPES, P. D.; FREITAS NETO, O. C.; BATISTA, D. F. A.; DENADAI, J.; ALARCON, M. F. F.; ALMEIDA, A. M.; VASCONCELOS, R. O.; SETTA, A.; BARROW, P. A.; BERCHIERI JUNIOR, A.. Experimental infection of chickens by a flagellated motile strain of Salmonella enterica serovar Gallinarum biovar Gallinarum. VETERINARY JOURNAL, v. 214, p. 40-46, . (11/23483-1, 11/14763-0)

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