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Evaluation of enamel caries-like lesions produced by a S. mutans biofilm

Grant number: 11/15973-9
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Health Sciences - Dentistry - Pediatric Dentistry
Principal researcher:Regina Maria Puppin Rontani
Grantee:Micaela Cardoso
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil


Routinely in vitro researches don't draw parallels progression and regression of the initial caries lesion, with clinical protocol parameters for diagnosis of this lesion as ICDAS. This project will be developed in order to identify the effect of demineralization needed to caries lesion in vitro production in bovine enamel, using Streptococcus mutans biofilms with clinical features similar to those found in ICDAS II (2009) criteria, codes 1, 2 and 3. This study aims to test the hypotheses that: i) different demineralization times produce artificial caries lesions comparable to those classified by the ICDAS II codes 1, 2, and 3; will be used the following evaluation parameters to identify the caries production, remineralization and cariogenic challenge: clinical parameters (visual inspection-ICDAS II (2009) and radiographic); morphologicals: topography and depth (MEV, polarized light microscopy, confocal laser scanning) and transverse microhardness (KHN). These parameters will be statistically compared using appropriate statistical test to verify the association between them (p<0,05) (AU)

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