Literature data demonstrate that the particle size of HDL has been a new and potentially important marker of coronary heart disease risk. Low concentrations of high density lipoproteins (HDL) are one of the factors for the development of atherosclerosis, the leading cause of death in developed and emerging countries. Changes in plasma levels of HDL may be associated with the chemical composition and particle size changes. However the literature is still controversial about the relationship between particle size and concentration of plasma HDL-cholesterol. Therefore, this work aims to evaluate the particle size of HDL in normo, hyper and hypoalphalipoproteinemia using the technique of Laser Light Scattering (LLS) and verifing the relationships of this measurements with plasma concentrationof HDL-cholesterol, its chemical composition, clinical data and early atherosclerosis to verify if the size of this lipoprotein is related to dyslipidemia and cardiovascular disease in humans.
News published in Agência FAPESP Newsletter about the scholarship: