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Physico-chemical and biochemical studies of high density lipoprotein in states of hypo and hyperalphalipoproteinemia: association with carotid artery intima-media thickness

Grant number: 11/16476-9
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): June 30, 2013
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal researcher:Eliana Cotta de Faria
Grantee:Fernanda Alexandre
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:06/60585-9 - Relation of the plasma HDL-cholesterol concentration with blood monocyte and whole body cholesterol metabolism parameters, AP.TEM


Literature data demonstrate that the particle size of HDL has been a new and potentially important marker of coronary heart disease risk. Low concentrations of high density lipoproteins (HDL) are one of the factors for the development of atherosclerosis, the leading cause of death in developed and emerging countries. Changes in plasma levels of HDL may be associated with the chemical composition and particle size changes. However the literature is still controversial about the relationship between particle size and concentration of plasma HDL-cholesterol. Therefore, this work aims to evaluate the particle size of HDL in normo, hyper and hypoalphalipoproteinemia using the technique of Laser Light Scattering (LLS) and verifing the relationships of this measurements with plasma concentrationof HDL-cholesterol, its chemical composition, clinical data and early atherosclerosis to verify if the size of this lipoprotein is related to dyslipidemia and cardiovascular disease in humans.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PARRA, ELIANE SOLER; PANZOLDO, NATALIA BARATELLA; DE SOUZA ZAGO, VANESSA HELENA; SCHERRER, DANIEL ZANETTI; ALEXANDRE, FERNANDA; BAKKARAT, JAMAL; NUNES, VALERIA SUTTI; NAKANDAKARE, EDNA REGINA; ROCHA QUINTAO, EDER CARLOS; NADRUZ-, JR., WILSON; et al. HDL Size is More Accurate than HDL Cholesterol to Predict Carotid Subclinical Atherosclerosis in Individuals Classified as Low Cardiovascular Risk. PLoS One, v. 9, n. 12, . (06/60585-9, 11/16476-9)
ALEXANDRE, F.; ZAGO, V. H. S.; PANZOLDO, N. B.; PARRA, E. S.; SCHERRER, D. Z.; VENDRAME, F.; NUNES, V. S.; GOMES, E. I. L.; MARCATO, P. D.; NAKANDAKARE, E. R.; et al. Reference values for high-density lipoprotein particle size and volume by dynamic light scattering in a Brazilian population sample and their relationships with metabolic parameters. Clinica Chimica Acta, v. 442, p. 63-72, . (06/60585-9, 11/16476-9)

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