|Support type:||Scholarships in Brazil - Master|
|Effective date (Start):||March 01, 2012|
|Effective date (End):||June 30, 2013|
|Field of knowledge:||Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology|
|Principal Investigator:||Eliana Cotta de Faria|
|Home Institution:||Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil|
|Associated research grant:||06/60585-9 - Relation of the plasma HDL-cholesterol concentration with blood monocyte and whole body cholesterol metabolism parameters, AP.TEM|
Literature data demonstrate that the particle size of HDL has been a new and potentially important marker of coronary heart disease risk. Low concentrations of high density lipoproteins (HDL) are one of the factors for the development of atherosclerosis, the leading cause of death in developed and emerging countries. Changes in plasma levels of HDL may be associated with the chemical composition and particle size changes. However the literature is still controversial about the relationship between particle size and concentration of plasma HDL-cholesterol. Therefore, this work aims to evaluate the particle size of HDL in normo, hyper and hypoalphalipoproteinemia using the technique of Laser Light Scattering (LLS) and verifing the relationships of this measurements with plasma concentrationof HDL-cholesterol, its chemical composition, clinical data and early atherosclerosis to verify if the size of this lipoprotein is related to dyslipidemia and cardiovascular disease in humans.