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Effects of gestational diabetes on Wistar rat ventral prostate: morphometrical analysis, cellular proliferation and death and expression of androgen receptor and prostatein

Grant number: 11/16522-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Biological Sciences - Morphology - Histology
Principal Investigator:Luis Antonio Justulin Junior
Grantee:Sérgio Alexandre Alcantara dos Santos
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Diabetes mellitus (DM) is a heterogeneous clinical symdrome caused by insulin depletion production by pancreatic beta cells or defects in insulin receptor from target cells, resulting in hyperglycemic metabolic disease. Gestational Diabetes causes fetal disturbs, such as excessive fetal growth (macrosomic), due higher glucose availability and growth factors stimulation. The higher birth weight is associated with higher risk to develop insulin resistance, obesity and type 2 DM in late life. Diabetes also affect the male reproductive system, specially testis and sex accessory glands. Besides many studies about diabetes effects on testicular function and fertility, the impact of gestational diabetes on prostate morphogenesis and maturation is still limited. The aim of this study is to evaluate the effects of gestational diabetes on prostate development, morphogenesis and maturation of prostate gland. It will be investigate the processes of cell proliferation and death, the gene and protein expression of androgen receptor and prostatein, an androgen regulated secretory protein in the ventral lobe from 60 and 120 days-old Wistar rats. It will be done morphological, morphometrical, immunohistochemical analyses associated with western blotting and RT-PCR reactions. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS, SERGIO A. A.; RINALDI, JAQUELINE C.; MARTINS, AMANDA E.; CAMARGO, ANA C. L.; LEONELLI, CARINA; DELELLA, FLAVIA K.; FELISBINO, SERGIO L.; JUSTULIN, JR., LUIS A.. Impact of gestational diabetes and lactational insulin replacement on structure and secretory function of offspring rat ventral prostate. General and Comparative Endocrinology, v. 206, p. 60-71, . (11/16522-0, 12/18100-9)
CAMARGO, ANA C. L.; DOS SANTOS, SERGIO A. A.; RINALDI, JAQUELINE C.; CONSTANTINO, FLAVIA B.; COLOMBELLI, KETLIN T.; SCARANO, WELLERSON R.; FELISBINO, SERGIO L.; JUSTULIN, LUIS A.. Streptozotocin-Induced Maternal Hyperglycemia Increases the Expression of Antioxidant Enzymes and Mast Cell Number in Offspring Rat Ventral Prostate. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology, v. 300, n. 2, p. 291-299, . (11/16522-0, 13/19673-5, 12/18100-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTOS, Sérgio Alexandre Alcantara dos. Efeitos do diabetes gestacional moderado e da reposição com insulina na lactação sobre a próstata ventral do rato Wistar. 2014. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Botucatu Botucatu.

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