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Evaluation of genotoxicity, mutagenicity, estrogenicity and toxicity of the Jaguari, Atibáia and Piracicaba rivers under the influence of the Paulinia refinery.

Grant number: 11/16552-7
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): April 30, 2013
Field of knowledge:Biological Sciences - Ecology - Ecosystems Ecology
Principal Investigator:Maria Aparecida Marin Morales
Grantee:Maria Tereza Pamplona Silva
Host Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil


Industrialization presents countless benefits, but it is also associated with environmental actions such as constant emission of toxic substances into the environment. Industrial activities release several chemical products that contaminate the several physical environments such as soil, air and water. Refining industry represents an important sector of the economy, but on the other hand it produces effluents that can be rich in heavy metals and other hazardous inorganic compounds, besides a great variety of organic substances with potential to interact with living organisms. Among the organic contaminants derived from petroleum, the most important are the polycyclic aromatic hydrocarbons (PAHs). These compounds, as well as their by-products, are associated with the increased incidence of several types of cancer in man. Due to these factors, there has been a stimulus to the development and application of new techniques that are able to assess in an efficient manner the environmental components derived from human activities. Thus, the present project aims to assess the genotoxicity, estrogenicity and toxicity of the waters of the Jaquari, Atibaia and Piracicaba rivers, which are in a region under the influence of the Paulínia refinery activity. To evaluate the waters of these rivers, techniques using two test organisms highly indicated, such as Saccharomyces cerevisiae (yeast) and human liver hepatocellular carcinoma cell line (HepG2), will be used. With these two organisms it will be developed the comet assay and the micronucleus test in human liver hepatocellular carcinoma cell line and tests of estrogenicity, toxicity and dioxin-like with Saccharomyces cerevisiae. The results obtained will allow the estimation of possible dangers that chemical substances released by this type of industry present, furthermore, the results will also allow a better knowledge about the mode of action of these compounds on cells and genetic material of the exposed organisms.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PAMPLONA-SILVA, MARIA TEREZA; CHRISTOFOLETTI MAZZEO, DANIA ELISA; BIANCHI, JAQUELINE; MARIN-MORALES, MARIA APARECIDA. Estrogenic Compounds: Chemical Characteristics, Detection Methods, Biological and Environmental Effects. WATER AIR AND SOIL POLLUTION, v. 229, n. 5, . (11/16552-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Maria Tereza Pamplona. Avaliação da toxicidade e caracterização de hidrocarbonetos presentes em águas de rios que recebem efluente de indústria petroquímica. 2013. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Rio Claro Rio Claro.

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