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Development and characterization of a composite-based bioactive glass Niobium/Phosphate and gutta-percha for endodontic use: Analysis of bond strength to dentin and nanoleakage.

Grant number: 11/18967-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): February 01, 2012
Effective date (End): April 30, 2014
Field of knowledge:Health Sciences - Dentistry - Endodontics
Principal Investigator:Giulio Gavini
Grantee:Ceci Nunes Carvalho
Home Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):12/18220-4 - Effect of composite and bioactive niobophosphate glass on biofilm formation, BE.EP.DR


Recently, biomaterials have been studied in the search for endodontic use of a material that can effectively plugging the root canal system, inhibiting or eliminating residual bacteria, preventing re-contamination with a suitable sealing and facilitating repair even in an environment periapical moist. The objective of this study is to develop and characterize a composite fillings based endodontic gutta-percha and niobium/phosphate glass containing calcium and sodium that will be obtained from the fusion of mixtures of ammonium hydroxide di-basic calcium oxide, sodium oxide and niobium oxide at 1400 ° C for 1 hour. Several tests will be performed in vitro using extracted human teeth to evaluate the bond strength of composite to dentin by testing ¼push-out, and analyzing the fracture pattern, and observing the patterns of nanoleakage interfaces via Scanning Electron Microscopy and Transmission. It is hoped that this composite one effective sealing the root canal system in a humid environment, reinforced by the formation of hydroxyapatite in dentin interface / filling without the use of any sealer.The data obtained from the test results will be tabulated and subjected to statistical analysis on the 5% level of significance.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARVALHO, C. N.; MARTINELLI, J. R.; BAUER, J.; HAAPASALO, M.; SHEN, Y.; BRADASCHIA-CORREA, V.; MANSO, A. P.; GAVINI, G. Micropush-out dentine bond strength of a new gutta-percha and niobium phosphate glass composite. International Endodontic Journal, v. 48, n. 5, p. 451-459, MAY 2015. Web of Science Citations: 19.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CARVALHO, Ceci Nunes. Effect of the addition of the niobophosphate bioactive glass in the gutta-percha: Development, characterization, bond strength to dentin and influence on biofilm formation. 2014. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Odontologia São Paulo.

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Filed patent(s) as a result of this research project

FORMULAÇÃO ODONTOLÓGICA ENDODÔNTICA E USO DA MESMA BR1020150093195 - Universidade de São Paulo (USP) . Giulio Gavini; Ceci Nunes Carvalho; Jose Roberto Martinelli - April 2015, 24