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Investigation of the role of low molecular weight protein tyrosine phosphatase (LMWPTP) in aggression and resistance of tumor cells

Grant number: 11/19626-1
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): January 01, 2012
Effective date (End): December 31, 2014
Field of knowledge:Biological Sciences - Biochemistry - Enzymology
Principal Investigator:Hiroshi Aoyama
Grantee:Camila de Andrade Camargo
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Each year, cancer has been established as a public health problem worldwide and is now the second leading cause of death by disease in developed countries. The process of tumor cell resistance to chemotherapy is a multifactorial mechanism which molecular details are still little known. In addition, metastasis is another central problem in cancer and the use of models that allow the investigation of mechanisms associated with tumor cells metastasis has also been common practice among researchers in recent years. Several studies have shown an increase of low molecular weight protein tyrosine phosphatase (LMWPTP) expression in different types of cancer and this event correlated to the stimulation of tumor progression and increasing of aggressiveness levels. Thus, LMWPTPs have been considered candidates for oncogenes and potential targets for the development of new anticancer therapies, thus justifying the need and importance of greater knowledge about their activities in normal and neoplastic cells with the multidrug resistance phenotype (MDR). However, a greater understanding of the role played by LMWPTP in the MDR development still depends on the establishment of this protein exact mechanism of action as well as their molecular targets determination. This project aims to silence the LMWPTP in LUCENA cell lines and verify his sensitivity in relation to chemotherapy; check for possible mutations in the K562 and LUCENA cell lines LMWPTP and analyze the role of LMWPTP in mitochondrial metabolism. (AU)

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