Breast cancer is a cancer that affects more women in the world, and the intense proliferation and tumor metastasis, the main factors responsible for high mortality of this cancer. The skeleton of metastatic cells is poorly structured, low anchor, which allows a more invasive cells. Both cell migration and anchorage in the substrate occurs through rearrangements of the actin cytoskeleton and cell processes are regulated by external signals and intracellular effectors. One of the main intracellular effectors is the protein associated with the Rho kinase (ROCK), and the increased expression of ROCK1 is related to tumor metastasis. Another process intrinsically related to the evolution of tumor formation and metastasis is degradation of the extracellular matrix. This process is influenced primarily as proteinases, and metalloproteinases (MMPs) the largest class of proteases in the human genome and MMP9 that has great invasive capacity. This study aims to evaluate the immunohistochemical expression of protein kinase associated with Rho (ROCK1) and matrix metalloproteinase (MMP9) in tumor tissue of 60 women affected by breast cancer, correlating the results with pathological variables, clinical, treatment and prognosis. Thus, the evaluation of protein ROCK1 and MMP9 enable progress in the search for new prognostic markers related to tumor invasion and metastasis of breast cancer.
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