Advanced search
Start date
Betweenand

IMMUNOHISTOCHEMICAL ANALYSIS OF PROTEINS INVOLVED IN METASTASIS OF BREAST CANCER: SEARCH OF PROGNOSTIC MARKERS

Grant number: 11/20578-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2012
Effective date (End): January 31, 2013
Field of knowledge:Health Sciences - Medicine
Principal researcher:Debora Aparecida Pires de Campos Zuccari
Grantee:Jenifer Bottino
Home Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil

Abstract

Breast cancer is a cancer that affects more women in the world, and the intense proliferation and tumor metastasis, the main factors responsible for high mortality of this cancer. The skeleton of metastatic cells is poorly structured, low anchor, which allows a more invasive cells. Both cell migration and anchorage in the substrate occurs through rearrangements of the actin cytoskeleton and cell processes are regulated by external signals and intracellular effectors. One of the main intracellular effectors is the protein associated with the Rho kinase (ROCK), and the increased expression of ROCK1 is related to tumor metastasis. Another process intrinsically related to the evolution of tumor formation and metastasis is degradation of the extracellular matrix. This process is influenced primarily as proteinases, and metalloproteinases (MMPs) the largest class of proteases in the human genome and MMP9 that has great invasive capacity. This study aims to evaluate the immunohistochemical expression of protein kinase associated with Rho (ROCK1) and matrix metalloproteinase (MMP9) in tumor tissue of 60 women affected by breast cancer, correlating the results with pathological variables, clinical, treatment and prognosis. Thus, the evaluation of protein ROCK1 and MMP9 enable progress in the search for new prognostic markers related to tumor invasion and metastasis of breast cancer.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.