Advanced search
Start date
Betweenand

The prostate ventral lobe organogenesis in the Mongolian Gerbil (Meriones unguiculatus) during the prenatal period

Grant number: 11/20358-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2012
Effective date (End): July 31, 2013
Field of knowledge:Biological Sciences - Morphology
Principal Investigator:Sebastião Roberto Taboga
Grantee:Bruno Domingos Azevedo Sanches
Home Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil

Abstract

The prostate is an exclusive gland of mammals reproductive tract which secretion is associated with maintenance and maturation of the spermatozoids allowing reproductive success. Its development takes place from an undifferentiated mesenchymal tissue named urogenital sinus (UGS), where initiates the process of prostate morphogenesis that is finely regulated by androgens and estrogens. Although there are several information regarding prostatic organogenesis in rodents such as rats and mice, nothing was described on this matter for Mongolian gerbil. Thus, considering that the employment of this animal model in studies with reproductive interest has been increased lately, the detailed knowledge of the events that occurs during prostatic organogenesis is needed to improve our understanding regarding the mechanisms involved in this gland formation. Thus, the aim of this study is to evaluate the patterns of budding and branching of the ventral lobe from 17th embryonic day till the first postnatal day in male gerbils. To this, the reproductive tract of these animals will be dissected and processed for paraffin inclusion. In addition, the slides will be subjected to citochemical and immunohystochemical techniques, being further destined to general morphological analyses and also for the characterization of the buds number in each phase of the development. From the obtained results, we aim to obtain the exactly description of the events evolution of the prostatic organogenesis in these animals, which can contributes to improve our understanding regarding the mechanisms involved in the development of this gland.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AZEVEDO SANCHES, BRUNO DOMINGOS; BIANCARDI, MANOEL FRANCISCO; ALCANTARA DOS SANTOS, FERNANDA CRISTINA; GOES, REJANE MAIRA; LEITE VILAMAIOR, PATRICIA SIMONE; TABOGA, SEBASTIAO ROBERTO. Budding Process During the Organogenesis of the Ventral Prostatic Lobe in Mongolian Gerbil. MICROSCOPY RESEARCH AND TECHNIQUE, v. 77, n. 6, p. 458-466, JUN 2014. Web of Science Citations: 14.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.