Two Copaifera species oleoresin: secondary metabolites isolation and development and validation of HPLC analytical methodology

• Grant number: 11/23493-7
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Effective date (Start): March 01, 2012
• Effective date (End): June 30, 2015
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Rodrigo Cassio Sola Veneziani
• Grantee: Ariana Borges Souza
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil

Abstract

Ariana Souza Borges was a interning at the "Grupo de Pesquisas em Produtos Naturais da UNIFRAN" (GPNUF - UNIFRAN) in 2008. During the entire year of 2009, she was a fellow of FAPESP and is currently finishing his master's project started in 2010, also with aid of FAPESP scholarship. In these years, the student has acquired experience in the isolation of secondary metabolites, especially diterpenes from oil-resin of Copaifera langsdorffii, and also in the development and validation of analytical methodologies. Knowledge of the chemical and biological potential represented by the oil-resin of all species of Brazilian Copaifera is essential for a better utilization of this valuable natural resource, however there is much to accomplish. Thus, given the need to develop further chemical-biological studies on Copaifera species and aiming a better use of expertise and experience obtained by the candidate over the years, is very appropriate to suggest the migration of Ariana to "doutorado direto". In this proposal, it is suggested that these further studies should be performed with the addition of another specie (Copaifera trapezifolia) to the initial masters proposal. With this in mind, this research project consists in a reformulation of the original one and includes new data and justification about the new Copaifera specie to be studied. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MIZUNO, CASSIA S.; SOUZA, ARIANA B.; TEKWANI, BABU L.; AMBROSIO, SERGIO R.; VENEZIANI, RODRIGO C. S.. Synthesis and biological evaluation of polyalthic acid derivatives for the treatment of neglected diseases. Bioorganic & Medicinal Chemistry Letters, v. 25, n. 23, p. 5529-5531, DEC 1 2015. (11/13630-7, 11/23493-7)

ARGENTIN, MARCELA NUNES; CRUZ, FELIPE DE PAULA NOGUEIRA; SOUZA, ARIANA BORGES; D'AUREA, ELISA MARCELA DE OLIVEIRA; BASTOS, JAIRO KENUPP; AMBROSIO, SERGIO RICARDO; VENEZIANI, RODRIGO CASSIO SOLA; CAMARGO, ILANA LOPES BARATELLA CUNHA; MIZUNO, CASSIA SUEMI. Synthesis and Antibacterial Activity of Polyalthic Acid Analogs. ANTIBIOTICS-BASEL, v. 12, n. 7, p. 12-pg., 2023-07-01. (13/07600-3, 19/04788-8, 13/07600-3, 11/13630-7, 22/07984-5, 11/23493-7)