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Identification of transcription factors possibly involved in mitochondrial biogenesis

Grant number: 12/00126-1
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): March 01, 2012
Effective date (End): July 31, 2014
Field of knowledge:Biological Sciences - Genetics - Plant Genetics
Principal researcher:Paulo Arruda
Grantee:Pedro Paulo Augusto Fabiano Arantes Pereira Barreto
Home Institution: Centro de Biologia Molecular e Engenharia Genética (CBMEG). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The mitochondrion is one of the most important cellular organelles. It has its own genome that acts in a coordinated manner with the nuclear genome regulating the expression of genes that together modulate different aspects of cellular metabolism. The metabolic activity of mitochondria are not limited only to the process of generating ATP, but also key activities to maintain cellular homeostasis. The process of mitochondrial biogenesis in animals is well known, having been identified transcription factors that regulate the process. In plants this process is still poorly known, and although is already known some of the tissues with high mitochondrial biogenesis, no transcription factor involved in the process habe been described yet. This project aims to use bioinformatics tools to handle datasets of transcriptomics to try to identify transcription factors possibly involved in mitochondrial biogenesis in plants. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BARRETO, PEDRO; OKURA, VAGNER KATSUMI; PENA NESHICH, IZABELLA AGOSTINHO; MAIA, IVAN DE GODOY; ARRUDA, PAULO. Overexpression of UCP1 in tobacco induces mitochondrial biogenesis and amplifies a broad stress response. BMC PLANT BIOLOGY, v. 14, MAY 28 2014. Web of Science Citations: 21.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BARRETO, Pedro Paulo Augusto Fabiano Arantes Pereira. Alterations on energy metabolism caused by mitochondrial uncoupling protein 1 (UCP1) overexpression in tobacco induce mitochondrial biogenesis and global stress response. 2014. Doctoral Thesis - Universidade Estadual de Campinas. Instituto de Biologia.

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