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Does Heteropterys aphrodisiaca treatment attenuate the cyclosporine side effects on testis and ventral prostate of wistar rats?

Grant number: 11/20611-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2012
Effective date (End): March 31, 2013
Field of knowledge:Biological Sciences - Morphology
Principal Investigator:Mary Anne Heidi Dolder
Grantee:Jacqueline Meriellen de Almeida
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Cyclosporin A (CsA) is an immunosupressive drug, widely used against auto-immune diseases and for treatment after organ transplants. However, its use causes various collateral effects, including nephrotoxicity and hepatotoxicity. It also caused damage to the male reproductive system and reduction of testorone production. Heteropterys aphrodisiaca is a plant typical of the Cerrado region of Brazil, popularly known as an aphrodisiac and a stimulating tonic. The infusion of roots of this plant has been observed to atenuate the damage caused by CsA in the testicles, ventral prostate and liver. The objective of this study is to confirm whether the infusion of H. aphrodisiaca roots reduces the collateral effects on the testicles and ventral prostate after cylosporine use during 21 days. This will be evaluated by morphologic, morphometric and steriological analysis of testicular and prostatic tissue.