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Potentially teratogenic identification in Brazilian clinical data base and family typical orofacial clefts

Grant number: 11/22200-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): March 01, 2012
Effective date (End): December 31, 2012
Field of knowledge:Health Sciences - Collective Health
Principal Investigator:Vera Lúcia Gil da Silva Lopes
Grantee:Bruna Henrique Bueno
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Introduction: The orofacial clefts comprise a complex and heterogeneous group, with worldwide prevalence of 1:600-1000 newborns. Among the various etiologies, the influence of teratogenic agents in its occurrence has been documented. However, information about this etiology, at the population level and in this specific group of congenital defects, is not characterized in Brazil. With support from the World Health Organization, FAPESP, CNPq and other agencies that support research, the Brazil Craniofacial Project designed and validated the Brazilian Clinical Data Base and Family Typical Orofacial Clefts (BBDCF). This is multicentered, based in the Department of Medical Genetics and has been active since 2008, with about 500 complete records to date. On this basis, all data are collected by clinical geneticists in a standardized way, resulting in consistent and detailed informations. Objective: Identify, in BBDCF, prenatal factors and their teratogenic potential for the occurrence of orofacial cleft. Method: A survey will be done by consulting the data at BBDCF on the first trimester of pregnancy, in order to identify potential teratogens. After this check a literature review will be conducted to identify individual teratogenic potential. The data will be initially analyzed in a descriptive way. Statistical tests will be employed according to the results obtained. The identification of substances used by the population in the critical period of orofacial development and their teratogenic potential may indicate population education strategies to prevent this and other birth defects.