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IL-18 effect on the modulation of monocyte dectin-1 receptor expression

Grant number: 12/01836-2
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2012
Effective date (End): December 31, 2012
Field of knowledge:Biological Sciences - Immunology - Applied Immunology
Principal Investigator:Luciane Alarcão Dias-Melicio
Grantee:Muriel Borçato Cestari
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

IL-18 is a proinflammatory cytokine and its role in paracoccidioidomycosis is not fully understood. This study aims to evaluate the role of IL-18 in the dectin-1 expression by human monocytes challenged with Paracoccidioides brasiliensis; evaluate the role of dectin-1 in the induction of IL-18, TNF-alpha and IL-10 by human monocytes challenged with Paracoccidioides brasiliensis; evaluate the role of dectin-1 and IL-18 in the monocyte activity against P. brasiliensis, by evaluating fungicidal activity and hydrogen peroxide production.

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