PHARMACOLOGICAL EVALUATION OF HYBRID NON STEROID COMPOUNDS DONORS OF HYDROGEN SULFIDE IN ARTRITIS (SYNOVITIS) AND CHRONIC PAIN

• Grant number: 11/16645-5
• Support Opportunities: Scholarships in Brazil - Master
• Start date: May 01, 2012
• End date: October 31, 2013
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Principal Investigator: Soraia Katia Pereira Costa
• Grantee: Filiphe de Paula Nunes Mesquita
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Pain is defined as an unpleasant sensory and emotional experience that is associated with real or potential injuries. It can be further classified as their time of action and intensity in acute or chronic, and as its location in somatic, visceral or neuropathic. Neuropathic pain affects mainly the components of the nervous system. This type of pain has great impact on the world's population, but the drugs and treatments available today do not necessarily mean cure of this disease. Rheumatoid arthritis is a chronic inflammatory disease that affects approximately 1-2% of the population around the world. It has great social economic imapct because of the expensive treatment. The gas hydrogen sulfide (H2S), was long considered just an environmental pollutant, but recent studies have demonstrated the physiological importance of this gas to mammals. He serves on several body processes such as inflammation, pain, blood pressure regulation. The use of hybrid compounds non-steroidal anti-inflammatory painkillers and donors of hydrogen sulfide has attracted attention because of the potential of beneficial effects and minimize harmful effects in cases where other NSAIDs are indicated. Because of these recent findings we evaluate the appropriate role of H2S in a model of rheumatoid arthritis and neuropathic pain induced by chemotherapy. Aspects will be evaluated as the parameters of inflammation, nociception and biochemics parameters. Another objective is to unravel the mechanism of action of the compound in model of carrageenan-induced arthritis model and model of neuropathic pain.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MESQUITA, Filiphe de Paula Nunes. Pharmacological evaluation of hybrid compounds anti-inflammatory and analgesic nonsteroidal donors of hydrogen sulfide in arthritis and chronic pain.. 2013. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.