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DETERMINATION OF THE SPONTANEOUS ACTIVITY OF RATS BY GRAVIMETRIC AND RELATIONS BETWEEN AEROBIC CAPACITY AND GENE EXPRESSION OF MCTS 1 AND 4: EFFECTS OF AGE AND PHYSICAL TRAINING.

Grant number: 11/16222-7
Support type:Scholarships in Brazil - Master
Effective date (Start): May 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Biological Sciences - Physiology - General Physiology
Principal researcher:Claudio Alexandre Gobatto
Grantee:Pedro Paulo Menezes Scariot
Home Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil

Abstract

The spontaneous and voluntary activities are extremely important and reflect behaviors characteristics of animal life. However in laboratory animals, exposure to constraints (cages) and deprivation of their natural locomotor behaviors, may promote the induction physical inactivity and compete with improvements in aerobic capacity and anaerobic, in experimental models involving chronic physical exercise. Although the spontaneous and voluntary activities are widely studied in behavioral areas, these parameters are poorly associated to the natural aerobic capacity of rodents, especially the expression of MCT1 and 4. In this sense, the purpose of this project is based on the determination of voluntary activities (activity wheel) and spontaneous (system via gravity load-cells (strain gages). The running wheel in the cage will be installed to measure daily activity voluntary. The gravimetry system will consist of equipment capable of analyzing the responses of force on the cage generated by muscle action, independent of kinematic activity of the animals with 24 hours monitoring in acquisition frequency of 1000 Hz. Measurements of aerobic exercise intensities and are obtained by anaerobic lactate minimum test. Thus, it is expected to examine relationships between the spontaneous and voluntary activity on the aerobic capacity and gene expression of MCT 1 and 4 depending on age, physical training, free access to wheel activity and ample space in the cage.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MENEZES SCARIOT, PEDRO PAULO; MANCHADO-GOBATTO, FULVIA DE BARROS; TORSONI, ADRIANA SOUZA; TORSONI, MARCIO ALBERTO; MASSELLI DOS REIS, IVAN GUSTAVO; BECK, WLADIMIR RAFAEL; GOBATTO, CLAUDIO ALEXANDRE. Wide housing space and chronic exercise enhance physical fitness and adipose tissue morphology in rats. APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, v. 40, n. 5, p. 489-492, . (11/16222-7, 12/20501-1)
SCARIOT, PEDRO P. M.; MANCHADO-GOBATTO, FULVIA DE BARROS; TORSONI, ADRIANA S.; DOS REIS, IVAN G. M.; BECK, WLADIMIR R.; GOBATTO, CLAUDIO A.. Continuous Aerobic Training in Individualized Intensity Avoids Spontaneous Physical Activity Decline and Improves MCT1 Expression in Oxidative Muscle of Swimming Rats. FRONTIERS IN PHYSIOLOGY, v. 7, . (14/10336-9, 11/16222-7, 12/20501-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SCARIOT, Pedro Paulo Menezes. Spontaneous activity of rats measured by gravimetry and relationships with aerobic capacity and gene expression of MCTs 1 and 4: effects of age and chronic exercise. 2014. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas Limeira, SP.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.