Mood disorders and anxiety in epilepsy: a clinical perspective, laboratory and morphological

• Grant number: 11/21818-6
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: May 01, 2012
• End date: August 31, 2016
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Fernando Cendes
• Grantee: Mateus Henrique Nogueira
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 14/08765-9 - Psychiatric disorders in epilepsy: a clinical, laboratory and morphological perspective, BE.EP.DR

Abstract

Epilepsy is a neurological disorder severe non-infectious higher incidence worldwide. The association between epilepsy and psychiatric disorders has long been known, but only in recent decades is significant studies that have emerged on the subject. Research shows that the occurrence of mood disorders and anxiety disorders is associated with the presence of an inflammatory response and morphological changes in brain structures. A better understanding of the functioning of these disorders as a consequence one would better match the treatment and conciliation, seeking a better result and a gain in quality of life of these patients. The objective of this project is to assess mood disorders and anxiety in patients with different types of epilepsy and see if there is any relationship between the occurrence of these comorbidities to the presence of an inflammatory response and brain morphological changes. Will be evaluated patients with different types of epilepsy are followed at Neurology Ambulatory of HC / Campinas - Unicamp and that meet the criteria for inclusion / exclusion. Patients will undergo a psychological evaluation with the use of instruments SCID-I, BDI, BAI and IDTN-E. Will be collected blood samples for analysis of the inflammatory response and magnetic resonance imaging to collect images of brain structures. The patients studied are divided into groups according to psychiatric diagnosis and type of epilepsy found. Clinical data will be tabulated and the parametric and nonparametric variables will be analyzed.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NOGUEIRA, MATEUS HENRIQUE; PIMENTEL DA SILVA, LUCIANA RAMALHO; VASQUES MOREIRA, JOSE CARLOS; RIBEIRO DE REZENDE, THIAGO JUNQUEIRA; ZANAO, TAMIRES ARAUJO; DE CAMPOS, BRUNNO MACHADO; YASUDA, CLARISSA LIN; CENDES, FERNANDO. Major Depressive Disorder Associated With Reduced Cortical Thickness in Women With Temporal Lobe Epilepsy. FRONTIERS IN NEUROLOGY, v. 10, JAN 17 2020. (13/07559-3, 14/08765-9, 11/21818-6)

NOGUEIRA, MATEUS H.; YASUDA, CLARISSA L.; COAN, ANA C.; KANNER, ANDRES M.; CENDES, FERNANDO. Concurrent mood and anxiety disorders are associated with pharmacoresistant seizures in patients with MTLE. Epilepsia, v. 58, n. 7, p. 1268-1276, JUL 2017. (11/21818-6, 14/08765-9)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

NOGUEIRA, Mateus Henrique. Mood and anxiety disorders in mesial temporal lobe epilepsy: a clinical, laboratory and morphological perspective. 2016. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.