Evaluation of the gastroprotective activity of the hydro-alcoholic extract (70%) obtained from the roots of Arrabidaea brachypoda (DC.) Bureau

• Grant number: 12/01868-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2012
• End date: March 31, 2013
• Field of knowledge: Biological Sciences - Pharmacology - Ethnopharmacology
• Principal Investigator: Alba Regina Monteiro Souza Brito
• Grantee: Amanda Franceschini Ghilardi
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The popular knowledge about the therapeutic activity of natural products has attracted the attention of the academic community in the search for new molecules and potential new drugs. The Cerrado is home to a wide variety of plants with potential medicinal use, the "cipó-una", as it is popularly called, or Arrabidaea brachypoda is used to treat chronic pain, joint pain and kidney stones. Studies have shown the presence of some substances such as phytosterols, flavonoids and tannins in its leaves and roots. This project proposes to investigate the alleged antiulcerogenic activity of the hydro-alcoholic extract of roots of the species Arrabidaea brachypoda. Recent studies have demonstrated the effectiveness of its extract in experimental models of pain and inflammation. Moreover, a previous study showed the presence of flavonoids and phenolic acids in hydro-alcoholic extract of the roots of Arrabidaea brachypoda. Thus, it is very promising to study its anti-ulcer activity. Moreover, peptic ulcer affects a large number of patients and the treatments currently available are limited, thus the search for new therapeutic alternatives is, at least appropriate. For this study, ulcers in male Wistar rats will be induced according to various models that resemble the main causes of ulcers in humans (alcohol, drugs, nonsteroidal anti-inflammatory and accumulation of duodenal and gastric secretions).We will assess the effect of the extract of Arrabidaea brachypoda at various doses compared to a control group. The results will be analyzed by counting the lesions and assessing biochemical parameters to determine the pharmacological mechanisms of action of the extract.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA ROCHA, CLAUDIA QUINTINO; DE-FARIA, FELIPE MEIRA; MARCOURT, LAURENCE; EBRAHIMI, SAMAD NEJAD; KITANO, BRUNA TIEMI; GHILARDI, AMANDA FRANCESCHINI; FERREIRA, ANDERSON LUIZ; DE ALMEIDA, ANA CRISTINA ALVES; DUNDER, RICARDO JOSE; MONTEIRO SOUZA-BRITO, ALBA REGINA; et al. Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols. Phytochemistry, v. 135, p. 93-105, MAR 2017. (12/01868-1, 14/03728-8, 09/52237-9)