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Renoprotective mechanisms of stem cells derived from adipose tissue in experimental models of chronic kidney disease in vivo and in vitro

Grant number: 11/22568-3
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): May 01, 2012
Effective date (End): April 30, 2014
Field of knowledge:Biological Sciences - Immunology
Principal Investigator:Niels Olsen Saraiva Câmara
Grantee:Cassiano Donizetti de Oliveira
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated research grant:07/07139-3 - The role of heme oxygenase 1 in different renal inflammatory process in experimental animal models, AP.TEM

Abstract

Clinically, there are many renal diseases with progressive nature, resulting in renal failure and need replacement therapy. Even with the advance of medicine in recent decades, the incidence and mortality of these diseases remain high, and the treatment is restricted to dialysis or kidney transplants. So, development of new effective therapeutic strategies becomes essential, and the use of animal models that simulate the clinical manifestations of kidney disease in humans is necessary. Still, because of the serious consequences of the progression of renal disease, alternative forms of therapy are needed, and this field is growing interest in stem cell treatment. Adult mesenchymal stem cells have demonstrated immunomodulatory and regenerative potential for kidney disease. More readily available and higher reparative potential, mesenchymal stem cells derived from adipose tissue (ASC) become potential therapeutic targets. Thus, in this work, we intend to study the mechanisms that involve the protection of the kidney tissue by ASC, resulting in less disease progression in experimental models in vivo and in vitro. (AU)