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Role of estradiol ín thirst, sodium appetite ánd neuroendocrine responses induced by Angiotensin II: cellular mechanisms

Grant number: 12/04620-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2012
Effective date (End): February 28, 2015
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:José Antunes Rodrigues
Grantee:Gislaine de Almeida Pereira
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The renin-angiotensin system plays an important role in controlling the homeostasis of body fluids, being the angiotensin II (Ang II) its main active hormone. The effects dipsogenic, natriorexigenic and neuroendocrine responses of ANG II are mediated mainly by AT1 receptors. In addition, this system is under the influence of female hormones, especially estrogen, which modulate the effects of ANG II mediated by AT1 receptors. However, the molecular and cellular mechanisms of interaction between estradiol and ANG II have not yet been elucidated in the literature. Moreover, the elucidation of the components of cell signaling cascade of AT1 and estrogen receptors provides important information about the role of estrogen modulating the effects of ANG II related hydromineral balance in physiological and pathophysiological conditions such as dehydration and hypovolemia. In this context, the objective of this study is to investigate the influence of estradiol on cell signaling of the AT1 receptor mediating the effects dipsogenic, natriorexigenic and neuroendocrine responses of ANG II induced by water deprivation, acute sodium depletion and central angiotensinergic stimulation in ovariectomized rats.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALMEIDA-PEREIRA, G.; COLETTI, R.; MECAWI, A. S.; REIS, L. C.; ELIAS, L. L. K.; ANTUNES-RODRIGUES, J. ESTRADIOL AND ANGIOTENSIN II CROSSTALK IN HYDROMINERAL BALANCE: ROLE OF THE ERK1/2 AND JNK SIGNALING PATHWAYS. Neuroscience, v. 322, p. 525-538, MAY 13 2016. Web of Science Citations: 6.

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