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Assessment of Depression, Anxiety, Quality of Life and Psychological Well-Being in Patients with Diagnosis of Multiple Endocrine Neoplasia Type 2.

Grant number: 12/04698-0
Support type:Scholarships in Brazil - Master
Effective date (Start): July 01, 2012
Effective date (End): March 31, 2014
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Delmar Muniz Lourenço Jr
Grantee:Karine Cândido Rodrigues
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Introduction: Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant disease caused by germline RET mutation, which runs with medullary thyroid carcinoma (MTC), pheochromocytoma (Pheo), and hyperparathyroidism. The MTC is a malignant neoplasm, poorly responsive to chemo / radiotherapy, which develops already in the 1st decade of life. Thus, prophylactic thyroidectomy is indicated before 5 or 10 years, depending on the mutated codon to ensure healing. However, many patients are diagnosed with advanced tumors in adulthood. Unlike most malignancies, the CMT is a slow-growing tumor and the patients with the diagnosis of cancer for decades. In addition, Feo may develop, predisposing them to risk of death from myocardial infarction or stroke at a young age. Added to stress such as risk of transmission to offspring, expected results of periodic examinations and risk of multiple surgeries. In contrast to clinical and genetic studies, there are few studies focusing on the psychological aspects of MEN2. The cancer patient can develop psychological symptoms: anxiety, depression, anxiety, fear of disease recurrence, psychosomatic disorders, stress resulting from operations and negative self-concept. Objectives: To assess anxiety and depression symptoms, quality of life, psychological adjustment, presence of guilt by self-reported disease transmission to children, knowledge of disease and treatment adherence. Methods: Evaluation of 50 patients belonging to 25 families with clinical / gene for MEN2. Methodology: Psychological assessment by semi-directed interview, Hospital Anxiety and Depression, European Organization for Research and Treatment of Cancer Quality of Life Scale, Mental Adjustment to Cancer and Factorial Structure. Data analysis will be carried out quantitatively and qualitatively.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RODRIGUES, KARINE C.; TOLEDO, RODRIGO A.; COUTINHO, FLAVIA L.; NUNES, ADRIANA B.; MACIEL, RUI M. B.; HOFF, ANA O.; TAVARES, MARCOS C.; TOLEDO, SERGIO P. A.; LOURENCO, JR., DELMAR M. Assessment of Depression, Anxiety, Quality of Life, and Coping in Long-Standing Multiple Endocrine Neoplasia Type 2 Patients. THYROID, v. 27, n. 5, p. 693-706, MAY 2017. Web of Science Citations: 6.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
RODRIGUES, Karine Cândido. Depression assessment, anxiety, quality of life and well-being psychological in patients diagnosed with cancer multiple endocrine type 2. 2015. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina São Paulo.

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