|Support type:||Scholarships in Brazil - Doctorate|
|Effective date (Start):||June 01, 2012|
|Effective date (End):||September 30, 2015|
|Field of knowledge:||Health Sciences - Medicine - Medical Clinics|
|Principal researcher:||Roberto Jorge da Silva Franco|
|Grantee:||Fernanda Stringuetta Belik|
|Home Institution:||Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil|
Chronic kidney disease (CKD) is defined as the progressive and irreversible loss of renal function. The most common risk factors for developing CKD are hypertension and diabetes mellitus. CKD patients have low functional capacity, due to cardiopulmonary, musculoskeletal, neurological, endocrine metabolic and electrolyte. There is an increased risk of developing cardiovascular disease in patients with CKD. As a result, physical training programs have been proposed aiming at the treatment of risk factors and their impact on quality of life. Depressive symptoms, slow cognitive and psychomotor commonly arise as neurological manifestations. Changes in cerebral hemodynamics may be relevant in the pathogenesis of cognitive dysfunction in hemodialysis. There are no reports in the literature on the influence of aerobic exercise on cerebral blood flow and its effects on cognitive function in these patients. As a result, this study aimed to assess the effect of aerobic training intradialítico in cerebral blood flow and its effects on cognitive function and quality of life in patients with chronic renal failure on hemodialysis at the Hospital of Botucatu. Participate in this project volunteers who undergo hemodialysis in the hospital mentioned, after signing the Instrument of Consent. Data will be collected on an initial assessment. Patients will undergo a series of tests that assess physical activity, cognitive function, dementia and quality of life. Also carry out cardiopulmonary exercise test, walk test six minutes and transcranial doppler. The intradialítico aerobic training program will last six months, being held three times a week. After the exercise program the patients will make a reassessment. Patients will be randomized into two groups according to the completion of the exercise protocol or not. Thus, it is expected to improve the aspects evaluated in transcranial doppler, the test of cognitive function and quality of life, beyond the parameters of cardiopulmonary exercise test and functional capacity. With these findings will be possible to evaluate the effectiveness of training intradialítico for patients with chronic renal failure.