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Influence of intradialytic aerobic training in cerebral blood flow and reflection on cognitive function and quality of life in chronic renal patients

Grant number: 11/20652-7
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2012
Effective date (End): September 30, 2015
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Roberto Jorge da Silva Franco
Grantee:Fernanda Stringuetta Belik
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Chronic kidney disease (CKD) is defined as the progressive and irreversible loss of renal function. The most common risk factors for developing CKD are hypertension and diabetes mellitus. CKD patients have low functional capacity, due to cardiopulmonary, musculoskeletal, neurological, endocrine metabolic and electrolyte. There is an increased risk of developing cardiovascular disease in patients with CKD. As a result, physical training programs have been proposed aiming at the treatment of risk factors and their impact on quality of life. Depressive symptoms, slow cognitive and psychomotor commonly arise as neurological manifestations. Changes in cerebral hemodynamics may be relevant in the pathogenesis of cognitive dysfunction in hemodialysis. There are no reports in the literature on the influence of aerobic exercise on cerebral blood flow and its effects on cognitive function in these patients. As a result, this study aimed to assess the effect of intradialytic aerobic training in cerebral blood flow and its effects on cognitive function and quality of life in patients with chronic renal failure on hemodialysis at the Hospital of Botucatu. Participate in this project volunteers who undergo hemodialysis in the hospital mentioned, after signing the Instrument of Consent. Data will be collected on an initial assessment. Patients will undergo a series of tests that assess physical activity, cognitive function, dementia and quality of life. Also carry out cardiopulmonary exercise test, walk test six minutes and transcranial doppler. The intradialytic aerobic training program will last six months, being held three times a week. After the exercise program the patients will make a reassessment. Patients will be randomized into two groups according to the completion of the exercise protocol or not. Thus, it is expected to improve the aspects evaluated in transcranial doppler, the test of cognitive function and quality of life, beyond the parameters of cardiopulmonary exercise test and functional capacity. With these findings will be possible to evaluate the effectiveness of intradialytic training for patients with chronic renal failure. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BELIK, FERNANDA STRINGUETTA; OLIVEIRA E SILVA, VIVIANA RUGOLO; BRAGA, GABRIEL PEREIRA; BAZAN, RODRIGO; VOGT, BARBARA PEREZ; TEIXEIRA CARAMORI, JACQUELINE COSTA; BARRETTI, PASQUAL; GONCALVES, RENATO DE SOUZA; FORTES VILLAS BOAS, PAULO JOSE; HUEB, JOAO CARLOS; et al. Influence of Intradialytic Aerobic Training in Cerebral Blood Flow and Cognitive Function in Patients with Chronic Kidney Disease: A Pilot Randomized Controlled Trial. NEPHRON, v. 140, n. 1, p. 9-17, . (11/20652-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BELIK, Fernanda Stringuetta. Influence of intradialytic aerobic training in cerebral blood flow and reflection on cognitive function and quality of life in chronic renal patients. 2016. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Medicina. Botucatu Botucatu.

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