| Grant number: | 12/00111-4 |
| Support type: | Scholarships in Brazil - Doctorate |
| Effective date (Start): | June 01, 2012 |
| Effective date (End): | March 31, 2016 |
| Field of knowledge: | Health Sciences - Medicine - Medical Clinics |
| Principal researcher: | Sara Teresinha Olalla Saad |
| Grantee: | Flávia Adolfo Corrocher |
| Home Institution: | Centro de Hematologia e Hemoterapia (HEMOCENTRO). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
Abstract Myelodysplastic syndrome (MDS) is caused by a heterogeneous group of disorders in hematopoietic stem cells characterized by dysplastic changes in the bone marrow and ineffective hematopoiesis. The consequences of this impaired hematopoiesis are peripheral blood cytopenias, that may involve all three segments of the blood: erythrocytes, leukocytes and platelets. Previous results of microarray identified several genes whose expression was modulated in CD34+ and stromal cells of patients with SMDs and also RNAs non-coding (ncRNAs) that possibly make up signaling networks that control, integrate and regulate mechanisms transcriptional, post transcriptional and epigenetic. The NR4A subfamily of nuclear receptors are transcription factors involved in various cellular functions in which exonic and intronic regions showed hyperexpression in microarray analysis performed on CD34+ cells in patients with MDS. There are only two studies in the literature relating these proteins with AML (acute myeloid leukemia) and MDS and the results are still contradictory. Therefore, the aim of this study is to investigate the role of coding and noncoding transcripts of these proteins in bone marrow disease through overexpression and functional studies of the same. | |
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