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THERAPEUTIC STUDY OF MPA INTRAVITREAL IMPLANT IN EXPERIMENTAL AUTOIMMUNE UVEITIS

Grant number: 12/05298-5
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2012
Effective date (End): August 31, 2015
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Dora Selma Fix Ventura
Grantee:Gabriela Lourençon Ioshimoto
Home Institution: Instituto de Psicologia (IP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:08/58731-2 - Vision as a sensitive indicator of conditions threatening retinal and central nervous system function, AP.TEM

Abstract

Uveitis is a chronic intraocular inflammation of the uvea (iris, choroid and ciliary body) and an important cause of blindness worldwide. The autoimmune uveitis (or noninfectious) can be triggered by environmental, genetic or immunological stimuli. In most cases, the causal agent of inflammation is unknown or undetectable. Mycophenolate mofetil (MMF) is a potent immunosuppressive drug taken orally that has been used successfully in the treatment of uveitis, but whose side effects often require interruption of treatment. MMF is a pro-drug which is converted in the liver to mycophenolic acid (MPA), the active immunosuppressor. To maintain concentration and release the drug in the target organ and reduce systemic and intraocular toxicity we will test the effects of a MPA biodegradable intravitreal implant in rabbit eyes. The first phase of this work aims to establish a functional profile of primary safety, pharmacokinetic and morphological study of the intravitreal implant of MPA (400 ¼g) and the second phase will examine treatment evolution in rabbit models of autoimmune uveitis using morphological and electrophysiological techniques.

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
IOSHIMOTO, Gabriela Lourençon. Therapeutic study of the MPA intravitreous implant in the experimental autoimmune uveitis. 2015. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Psicologia São Paulo.

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