Xylitol, a sugar substitute, has gained attention in the last years due to its antimicrobial, anticaries and remineralizing properties. Thus, effective and safe vehicles are desirable for caries control. Considering that sodium fluoride varnishes are broadly employed in Dentistry to control caries, the present study aims to evaluate the efficacy of a new varnish having xylitol as active principle, in different concentrations, associated or not with fluoride for: 1) in vitro inhibit demineralization and increase remineralization of bovine enamel and 2) to clinically control active non-cavitated caries lesions (white-spot lesions). For this purpose, in phase 1, the effect of 7 different varnishes (10% Xylitol, 20% Xylitol, 10% Xylitol + 5% NaF, 20% Xylitol + 5% NaF, Duofluoride XII®, Duraphat® and placebo varnish - without xylitol or fluoride) on the inhibition of demineralization and increase of remineralization of sound or artificially demineralized bovine enamel, using an in vitro pH-cycling model will be evaluated (total n = 280 - 20 for each group). Data will be tested for normality and homocedasticity for selection of the appropriated statistical test to be used. The significance level will be set at 5%.
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