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Studies of the essential oil of chemical Cymbopogon winterianus Jowitt (Poaceae) guides by evaluation of in vitro antiproliferative activity

Grant number: 12/04822-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2012
Effective date (End): December 31, 2012
Field of knowledge:Health Sciences - Pharmacy - Pharmacognosy
Principal Investigator:Vera Lúcia Garcia
Grantee:Fernanda Greco Faria
Home Institution: Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA). Universidade Estadual de Campinas (UNICAMP). Paulínia , SP, Brazil

Abstract

The importance of study the antitumoral activity of medicinal plants is related to the fact that cancer is a major public health problems in worldwide. In the United States, there are about one million new cases each year. In Brazil, the number of cancer cases increases every year and in southeastern Brazil, malignant tumors are the second leading cause of death.Since 1996, the CPQBA / UNICAMP developed screening studies of medicinal plants with potential anticancer activity, following the same methodology of the National Cancer Institute (NCI, USA). Preliminary results obtained by our research group revealed the potential antiproliferative activity in vitro of essential oil from leaves, stems, roots and xilopodios of the Viguiera robusta Were evaluated 10 tumor cell lines: colon (HT-29), lung (NCI-H460), breast (MCF-7), Glia (U251), Kidney (786-O), ovarian (OVCAR-3) phenotype Ovary multidrug resistance (NCI-ADR/RES), prostate (PC-3), leukemia (K562) and keratimocyt human (HaCaT). The analysis of in vitro antiproliferative activity of the OE fresh leaves of V. robusta was selective for tumor cell lines leukemia (K-562), Kidney (786-0), and Glial U251 Ovary with multidrug-resistant phenotype (NCI-ADR/RES). These results motivated us to propose this research project, aiming to carry out chemical studies of essential oils (EO's) of fresh and dried leaves of V. robusta bioguiado robust assays for in vitro antiproliferative activity to identify active compounds.