Role of serotonergic receptors of periaqueductal gray on antinociception of mice c...
| Grant number: | 12/06009-7 |
| Support type: | Scholarships abroad - Research Internship - Doctorate (Direct) |
| Effective date (Start): | September 01, 2012 |
| Effective date (End): | August 31, 2013 |
| Field of knowledge: | Biological Sciences - Pharmacology - Neuropsychopharmacology |
| Principal Investigator: | Azair Liane Matos Do Canto de Souza |
| Grantee: | Daniela Baptista de Souza |
| Supervisor abroad: | Carla Ghelardini |
| Home Institution: | Centro de Educação e Ciências Humanas (CECH). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil |
| Local de pesquisa : | Università degli Studi di Firenze, Italy |
| Associated to the scholarship: | 09/17938-6 - Role of serotonergic receptors of periaqueductal gray on antinociception of mice confined to open arms the elevated plus-maze, BP.DD |
Abstract Clinical and experimental evidence suggest an intrinsic relationship between some pain condition and emotional disturbances. Therefore patients in cancer treatment are extremely vulnerable group affective disorders due their pathological condition, or as a consequence of therapies use in treatment. Oxaliplatin (OXL) is a second-line chemotherapy agent, has been used as first-line for some specific types of cancer (colorectal and ovarian). The OXL has less severe side effects when compared to others chemotherapic agents, however the most common side effect is peripheral neuropathy or neurological toxicity. Neuropathic pain, similar that to occurs in different types of chronic pain, triggers activation of the nervous central system regions that modulate affective reactions and pain, as the amygdala, periaqueductal gray and areas of the cerebral cortex related to emotions. The neurotransmitter serotonin may be involved in mechanisms related to neuropathic pain due their projections ascendants (e.g. amygdala and periaqueductal gray) or for the dorsal horn of the spinal cord. In this sense, administration of compounds that act in serotoninergic pathways has been used in studies to clarify the mechanism involved in the modulation of pain. Thus, considering evidence suggesting the possible role of fluoxetine analgesic in rodents, this study aim to evaluate the behavioral and molecular effects triggered by treatments (acute and chronic) with fluoxetine on neuropathic pain induced by oxaliplatin. (AU) | |