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Role of serotoninergic neurotransmission on oxaliplatin-induced neuropathy in mice

Grant number: 12/06009-7
Support Opportunities:Scholarships abroad - Research Internship - Doctorate (Direct)
Effective date (Start): September 01, 2012
Effective date (End): August 31, 2013
Field of knowledge:Biological Sciences - Pharmacology - Neuropsychopharmacology
Principal Investigator:Azair Liane Matos Do Canto de Souza
Grantee:Daniela Baptista de Souza
Supervisor: Carla Ghelardini
Host Institution: Centro de Educação e Ciências Humanas (CECH). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Research place: Università degli Studi di Firenze, Italy  
Associated to the scholarship:09/17938-6 - Role of serotonergic receptors of periaqueductal gray on antinociception of mice confined to open arms the elevated plus-maze, BP.DD


Clinical and experimental evidence suggest an intrinsic relationship between some pain condition and emotional disturbances. Therefore patients in cancer treatment are extremely vulnerable group affective disorders due their pathological condition, or as a consequence of therapies use in treatment. Oxaliplatin (OXL) is a second-line chemotherapy agent, has been used as first-line for some specific types of cancer (colorectal and ovarian). The OXL has less severe side effects when compared to others chemotherapic agents, however the most common side effect is peripheral neuropathy or neurological toxicity. Neuropathic pain, similar that to occurs in different types of chronic pain, triggers activation of the nervous central system regions that modulate affective reactions and pain, as the amygdala, periaqueductal gray and areas of the cerebral cortex related to emotions. The neurotransmitter serotonin may be involved in mechanisms related to neuropathic pain due their projections ascendants (e.g. amygdala and periaqueductal gray) or for the dorsal horn of the spinal cord. In this sense, administration of compounds that act in serotoninergic pathways has been used in studies to clarify the mechanism involved in the modulation of pain. Thus, considering evidence suggesting the possible role of fluoxetine analgesic in rodents, this study aim to evaluate the behavioral and molecular effects triggered by treatments (acute and chronic) with fluoxetine on neuropathic pain induced by oxaliplatin. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BAPTISTA-DE-SOUZA, DANIELA; MANNELLI, LORENZO DI CESARE; ZANARDELLI, MATTEO; MICHELI, LAURA; NUNES-DE-SOUZA, RICARDO LUIZ; CANTO-DE-SOUZA, AZAIR; GHELARDINI, CARLA. Serotonergic modulation in neuropathy induced by oxaliplatin: Effect on the 5HT(2C) receptor. European Journal of Pharmacology, v. 735, p. 141-149, . (12/06009-7)

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