Study of physical properties of giant vesicles in presence of oxidized lipids

• Grant number: 12/06208-0
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: September 01, 2012
• End date: December 31, 2012
• Field of knowledge: Biological Sciences - Biophysics - Molecular Biophysics
• Principal Investigator: Rosangela Itri
• Grantee: Helena Couto Junqueira
• Supervisor: Carlos Manuel Venâncio Marques Serra
• Host Institution: Instituto de Física (IF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: Institut Charles Sadron (ICS), France
• Associated to the scholarship: 11/00963-8 - Photosensitization mechanisms in lipid membranes: the role of lipid hydroperoxides and the lipid rafts formation., BP.PD

Abstract

The oxidative stress cause the lipid peroxidation that cause damage in the membrane and triggers signal cascades inducing apoptosis. The aim of this project is study the role of lipid hydroperoxide and the lipid raft formation. The studies will be performed in binary and ternary mixtures of lipids in presence of oxidized lipids. The informations about domain formation and membrane properties, as area increase, permeability and elasticity will help us to understand the role of lipid hidroperoxide in the photosensitization mechanisms. (AU)