Chromosomal alterations profiling in gliomas

• Grant number: 12/08287-4
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Effective date (Start): September 01, 2012
• Effective date (End): November 30, 2012
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Rui Manuel Vieira Reis
• Grantee: Lucas Tadeu Bidinotto
• Supervisor: Chris Jones
• Host Institution: Hospital do Câncer de Barretos. Fundação Pio XII (FP). Barretos , SP, Brazil
• Research place: Institute of Cancer Research (ICR), England
• Associated to the scholarship: 11/08523-7 - Chromosomal alterations profiling in brain tumors (medulloblastomas and gliomas): the impact in the identification of new tumorigenic pathways, BP.PD

Abstract

Gliomas are the most frequent and malignant tumors within the Central System Nervous (CNS) tumors. They are an incurable neoplasia, with a survival average of approximately 13 months, and less than 2% of the patients survive 5 years after the treatment. The low success in the treatment of these tumors is, in part, due to the low understanding of their molecular bases. The present project is divided in 3 parts: (a) identification of gains or losses in chromosomal regions of a set of gliomas (frozen tissue and primary culture) through CGH-array; (b) application of specific algorithms (Neighborhood Breakpoint Conservation) for the evaluation of structural variants, truncated genes and genetic fusions; (c) correlation of the data with the variables of the patients. We intend to identify, through a novel approach, genetic alterations that rule the evolution of gliomas, allowing the identification of potential biomarkers of diagnosis, prognosis and therapy response, fundamental for a new clinical approach on these tumors. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MACKAY, ALAN; BURFORD, ANNA; CARVALHO, DIANA; IZQUIERDO, ELISA; FAZAL-SALOM, JANAT; TAYLOR, KATHRYN R.; BJERKE, LYNN; CLARKE, MATTHEW; VINCI, MARA; NANDHABALAN, MEERA; et al. Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. CANCER CELL, v. 32, n. 4, p. 520+, OCT 9 2017. (11/08523-7, 12/08287-4)

BIDINOTTO, LUCAS TADEU; TORRIERI, RAUL; MACKAY, ALAN; ALMEIDA, GISELE CARAVINA; VIANA-PEREIRA, MARTA; CRUVINEL-CARLONI, ADRIANA; SPINA, MARIA LUISA; CAMPANELLA, NATHALIA CRISTINA; DE MENEZES, WEDER PEREIRA; CLARA, CARLOS AFONSO; et al. Copy Number Profiling of Brazilian Astrocytomas. G3-GENES, GENOMES, GENETICS, v. 6, n. 7, p. 1867-1878, JUL 1 2016. (12/08287-4, 11/08523-7, 12/19590-0, 13/25787-3)

CRUVINEL-CARLONI, ADRIANA; SILVA-OLIVEIRA, RENATO; TORRIERI, RAUL; BIDINOTTO, LUCAS TADEU; BERARDINELLI, GUSTAVO NORIZ; OLIVEIRA-SILVA, VIVIANE ALINE; CLARA, CARLOS AFONSO; DE ALMEIDA, GISELE CARAVINA; MARTINHO, OLGA; SQUIRE, JEREMY ANDREW; et al. Molecular characterization of short-term primary cultures and comparison with corresponding tumor tissue of Brazilian glioblastoma patients. TRANSLATIONAL CANCER RESEARCH, v. 6, n. 2, p. 332+, APR 2017. (11/08523-7, 12/08287-4, 12/19590-0)

BIDINOTTO, LUCAS TADEU; SCAPULATEMPO-NETO, CRISTOVAM; MACKAY, ALAN; DE ALMEIDA, GISELE CARAVINA; SCHEITHAUER, BERND WALTER; BERARDINELLI, GUSTAVO NORIZ; TORRIERI, RAUL; CLARA, CARLOS AFONSO; FELTRIN, LEONIR TEREZINHA; VIANA-PEREIRA, MARTA; et al. Molecular Profiling of a Rare Rosette-Forming Glioneuronal Tumor Arising in the Spinal Cord. PLoS One, v. 10, n. 9, SEP 15 2015. (11/08523-7, 12/08287-4, 12/19590-0)