Carcinoma ex pleomorphic adenoma (CXPA) is an aggressive neoplasm, and its pathogenesis is still unclear, although it is believed to result from the accumulation of genetic alterations in pleomorphic adenomas (PAs) with long duration. In this project we will study a group of CXPAs composed of tumors in different stages of carcinogenesis (intracapsular, minimally and frankly invasive), and classified according to histologic subtypes by array-comparative genomic hybridization (array-CGH). The literature review shows that this technique has been used to explore chromosomal changes only in a few cases of CXPA. Array-CGH will allow us a global analysis of changes in chromosome copy number in a representative sample, unlike the traditional cytogenetic techniques. Tumor cells have multiple gains and losses of whole chromosomes or arms, therefore, the array-CGH can potentially reveal copy number changes in chromosomal locus unexplored. The study of a group of CXPA in different stages of carcinogenesis with this technique will enable the identification of changes in copy number of chromosomal regions associated with tumor progression. The search for sites of genes involved in tumor progression may provide prognostic indicators of clinical disease. (AU)
News published in Agência FAPESP Newsletter about the scholarship:
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARIANO, FERNANDA VIVIANE;
MAION CASARIM, ANDRE LUIS;
MARTINS, ANTONIO SANTOS;
SCARINI, JOAO FIGUEIRA;
DE LIMA SOUZA, REYDSON ALCIDES;
EGAL, ERIKA SAID;
KOWALSKI, LUIZ PAULO;
VICTORINO KREPISCHI, ANA CRISTINA;
Somatic copy number alterations in pleomorphic adenoma and recurrent pleomorphic adenoma.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY,
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