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Evaluation of surface enhanced Raman spectroscopy on filter paper substrate and chemometric methods in determination of drugs

Grant number: 12/04321-3
Support type:Scholarships in Brazil - Master
Effective date (Start): July 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal researcher:Renato Lajarim Carneiro
Grantee:Loriz Francisco Sallum
Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil


Raman spectroscopy has been used in pharmaceutical analysis in recent decades due to advances in this technique, related to the development of electronic, optics and fundamental studies. Some problems related with the analysis of substances using classical methods have been achieved with high accuracy and good levels of selectivity by using of surface enhanced Raman spectroscopy. Due to some advantages such as the signal amplification and fast data acquisition, SERS has become a useful analytical tool in the quantification of active ingredients, contaminants detection and in many others sciences. The aim of this work is to build calibration models to ibuprofen, indomethacin and benzydamine and quantify these analytes in comercial products using SERS. The silver nanoparticles will be produced using filter paper as substrate being evaluate the substrate pretreatment and 1064 and 785 1/cm lasers in Raman analyses. The data set will be analyzed by use of chemometric tools, such as partial least squares (PLS), principal component regression (PCR), multivariate curve resolution by alternating least squares (MCR-ALS) and principal component analysis (PCA). The results will be evaluated by cross validation and external validation.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SALLUM, LORIZ FRANCISCO; FELIPE SOARES, FREDERICO LUIS; ARDILA, JORGE ARMANDO; CARNEIRO, RENATO LAJARIM. Determination of acetylsalicylic acid in commercial tablets by SERS using silver nanoparticle-coated filter paper. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 133, p. 107-111, DEC 10 2014. Web of Science Citations: 15.
SALLUM, LORIZ FRANCISCO; FELIPE SOARES, FREDERICO LUIS; ARDILA, JORGE ARMANDO; CARNEIRO, RENATO LAJARIM. Optimization of SERS scattering by Ag-NPs-coated filter paper for quantification of nicotinamide in a cosmetic formulation. Talanta, v. 118, p. 353-358, JAN 15 2014. Web of Science Citations: 20.

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