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Ageing effects in the myocardium plasticity of Spix's yellow-toothed cavies (Galea spixii - Wagler, 1831)

Grant number: 12/10596-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): March 01, 2013
Effective date (End): February 28, 2014
Field of knowledge:Biological Sciences - Morphology - Anatomy
Principal Investigator:Antonio Augusto Coppi Maciel Ribeiro
Grantee:Caroline Aparecida Gonçalves
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Cardiovascular diseases commonly occur in older individuals and are frequently the cause of functional loss and death. However, the ageing effects of the on cardiac structure and function are still unknown. Although some morphoquantitative data about cardiac tissue have been documented in literature, these results are commonly generated by bidimensional morphometric methods, which are potential sources of inaccuracy and "bias binding". The use of modern morphoquantitative methods (stereological methods) in cardiac research is still rare. So, the effects of ageing in the three-dimensional microstructure and plasticity of cardiomyocytes will be studied during the post-natal development of brasilian wild rodents (Spix's Yellow-toothed Cavies), with particular approach in the ageing period. It is expected that the results generated by this research can advance the knowledge about the effects of ageing in the myocardium, which can be advantageous on veterinary medicine cardiology, that is commonly read with animals with larger body surface than that of laboratory animals, such as rat and mouse.