Effects of adding mananoproteínas derived from yeast cell walls on immunological parameters of adult dogs and seniors

• Grant number: 11/17036-2
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2012
• End date: January 31, 2014
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Márcio Antonio Brunetto
• Grantee: Fernanda Sant Anna Kroll
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

The market for pet food has been growing along with the search for foods that promote health and well-being of animals. In older dogs especially the nutritional intervention aims to extend and enhance the quality of life, as well as delay the onset of disorders and diseases related to aging. It is believed that the benefits of the active fractions of mananoproteínas (FAM), obtained from the extraction and fractionation of the cell wall of yeast (Saccharomyces cerevisiae), including blocking the colonization of pathogenic bacteria, modulation of the immune system and modification of the morphology bowel. This study aims to evaluate the potential immunological effects of EGF on dogs of different ages. Will be employed with three diets isonutritives 0% inclusion of EGF (T0 - negative control), 0.04% FAM (T40) and 0.08% FAM (T80). Will be used a total of 12 beagle dogs, six adult dogs aged two to six years and six aged dogs over the age of 10 years. The treatments will result from the combination of two factors, two levels with age (adults and elderly) and diet with three levels (T0, T40 and T80), yielding six treatments, which will be distributed in six blocks, with the blocking factor repetition Experimental. The data will be submitted to analysis of variance with repeated measures. For the quantification of blood leukocytes and immunophenotypic phagocytosis assay, each treatment will be measured at zero, 14 and 28. For evaluation hematological, biochemical, cell proliferation assay, determining the production of reactive intermediates of oxygen and nitrogen, evaluation of fecal IgA concentration and delayed hypersensitivity test, each treatment will be evaluated at zero and 28 days. The differences of means are compared by F test analysis of variance and contrasts of orthogonal polynomials, evaluated by the GLM procedure of the software. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KROLL, F. S. A.; PUTAROV, T. C.; ZAINE, L.; VENTURINI, K. S.; AOKI, C. G.; SANTOS, J. P. F.; PEDRINELLI, V; VENDRAMINI, T. H. A.; BRUNETTO, M. A.; CARCIOFI, A. C.. Active fractions of mannoproteins derived from yeast cell wall stimulate innate and acquired immunity of adult and elderly dogs. ANIMAL FEED SCIENCE AND TECHNOLOGY, v. 261, MAR 2020. (11/17036-2)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

KROLL, Fernanda Sant Anna. Efeitos da adição de mananoproteínas derivadas da parede celular de leveduras sobre parâmetros imunológicos de cães adultos e idosos. 2014. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.