Effects of restraint stress on regulation of dendritic cells

• Grant number: 12/09332-3
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2012
• End date: February 28, 2014
• Field of knowledge: Biological Sciences - Immunology
• Principal Investigator: Cristina de Oliveira Massoco Salles Gomes
• Grantee: Ana Paula Nascimento de Lima
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The effects of stress are constant factors and important components in one's life and cause relevant changes on the immune system. Dendritic cells (DCs) are antigen presenting cells with a unique ability to activate T lymphocytes. These cells are important elements of the link between innate and adaptive immune responses. However, the pathways involved in regulating these cells still remain unclear. Thus, this project aims to investigate the effects of restraint stress on the regulation of dendritic cells (DCs) in rats. DCs will be analyzed in the stage of differentiation, endocytic capacity and antigen presenting function.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

LIMA, Ana Paula Nascimento de. Effects of acute restraint stress on phenotypic and functional characterization of dendritic cells in Balb/c mice. 2014. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.