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Theranostic nanomaterials applied to the cancer diagnosis and treatment and nanotoxicity studies

Grant number: 12/11166-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2012
Effective date (End): June 20, 2016
Field of knowledge:Physical Sciences and Mathematics - Physics - Condensed Matter Physics
Principal Investigator:Valtencir Zucolotto
Grantee:Valeria Spolon Marangoni
Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Associated scholarship(s):14/13645-2 - Development of cell-membrane coatings for the stealth delivery of MRI-active nanoparticles, BE.EP.DR


Recent advances in nanoscience and nanotechnology have expanded our ability to develop multifunctional nanostructures that combine therapeutics and diagnostics functions in a unique composite. These theranostic materials have shown to be interesting for many applications, mainly in early detection and treatment of cancer. The versatility of these structures is due the possibility of incorporation of many kinds of molecules on the nanoparticle surface, and therefore they are able to perform multiple functions. In this project, nanostructures materials containing metallic and/or magnetic nanoparticles or nanorods, polymers and recognition molecules such as aptamers and antibodies will be development. Chemotherapeutic drugs may also be incorporated to this system, allowing the delivery of these drugs directly to tumor cells and their release by magneto or photothermia. The interaction between these components will be studied using spectroscopic, microscopy and calorimetric techniques to obtain systems with high stability and well defined properties that are important for medical applications. Furthermore, we will investigate the in vitro toxicity as well as the specificity and interaction of the developed nanocomplex with tumor and healthy cells. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MAYRINK NOGUEIRA, PATRICIA FRANKLIN; MARANGONI, VALERIA SPOLON; ZUCOLOTTO, VALTENCIR. The aspect ratio of gold nanorods as a cytotoxicity factor on Raphidocelis subcaptata. Environmental Research, v. 191, . (12/11166-4)
MARANGONI, VALERIA S.; BERNARDI, JULIANA CANCINO; REIS, IANNY B.; FAVARO, WAGNER J.; ZUCOLOTTO, VALTENCIR. Photothermia and Activated Drug Release of Natural Cell Membrane Coated Plasmonic Gold Nanorods and beta-Lapachone. ACS APPLIED BIO MATERIALS, v. 2, n. 2, p. 9-pg., . (12/11166-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MARANGONI, Valeria Spolon. Theranostic nanomaterials applied to the cancer diagnostic and therapy and nanotoxicity studies. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Física de São Carlos (IFSC/BT) São Carlos.

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