Criteria Analisys for Ventilatory Support Adjustment of Mechanical Ventilation

• Grant number: 12/09170-3
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: August 01, 2012
• End date: November 30, 2016
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Pedro Caruso
• Grantee: Renata Pletsch Assunção
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated research grant: 10/08947-9 - Evaluation of INS and expiratory muscles in respiratory diseases, AP.TEM

Abstract

The evaluation of the kinematic of the respiratory muscles (ins and expiratory) and their functional and clinical contributions to respiratory diseases are outstanding in the scientific context. The indications for mechanical ventilation (MV) include excessive work of breathing, with or without evidence of respiratory muscle fatigue. The setting of the VM is still a challenge because it is based on criteria understudied, often subjective and observer-dependent. Despite several studies, to our knowledge has never been done before is the precise definition of the optimal range of ventilatory support, ie the interval between the inspiratory muscle fatigue and their excessive development of relaxation or hyperinflation. Novel and recognizable diagnostic techniques will be applied, as maximal magnetic stimulation of phrenic nerve, transdiaphragmatic pressure measurement, electromyogram of accessory muscles for ventilation, and synchrony of thoracic subcompartments during respirations, with all measurements being done at rest and during cardiopulmonary exercise as well. Our objective is the human and diagnostic development about the knowledge of dysfunctions of the ventilatory muscles and its repercussions, making possible a comprehensive understanding of the pathophysiology and, in this way, new design of future interventions for these respiratory diseases.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PLETSCH-ASSUNCAO, RENATA; PEREIRA, MAYRA CALEFFI; FERREIRA, JEFERSON GEORGE; CARDENAS, LETICIA ZUMPANO; PEREIRA DE ALBUQUERQUE, ANDRE LUIS; RIBEIRO DE CARVALHO, CARLOS ROBERTO; CARUSO, PEDRO. Accuracy of Invasive and Noninvasive Parameters for Diagnosing Ventilatory Overassistance During Pressure Support Ventilation{*}. Critical Care Medicine, v. 46, n. 3, p. 411-417, MAR 2018. (12/09170-3, 10/08947-9)

PLETSCH-ASSUNCAO, RENATA; PEREIRA, MAYRA CALEFFI; FERREIRA, JEFERSON GEORGE; CARDENAS, LETICIA ZUMPANO; PEREIRA DE ALBUQUERQUE, ANDRE LUIS; RIBEIRO DE CARVALHO, CARLOS ROBERTO; CARUSO, PEDRO. Accuracy of Invasive and Noninvasive Parameters for Diagnosing Ventilatory Overassistance During Pressure Support Ventilation*. Critical Care Medicine, v. 46, n. 3, p. 7-pg., 2018-03-01. (10/08947-9, 12/09170-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ASSUNÇÃO, Renata Pletsch. Analysis of criteria for ventilatory support adjustment of mechanical ventilation. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.