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Role of the adaptor protein MyD88 on the placental Malaria

Grant number: 12/14715-9
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2012
Effective date (End): August 31, 2014
Field of knowledge:Biological Sciences - Parasitology - Protozoology of Parasites
Principal Investigator:Cláudio Romero Farias Marinho
Grantee:Lutero Augusto Hasenkamp
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Each year at least 50 million pregnant women are exposed to malaria and this represents a high risk of death for the mother and growing fetus. Placental malaria (PM) is characterized by sequestration of parasites in the placenta, and consequent maternal anemia, intrauterine growth retardation, and decreased fetal viability. The large number of factors that are potentially involved in PM, associated with the great difficulties in the study of this disease in humans, makes the molecular basis of placental dysfunction still remain poorly understood. Toll-like receptors (TLR) are the main route by which the innate immune system recognizes and quickly responds to infectious agents and the adapter molecule MyD88 is a key part in the cascade of intracellular signaling of these receptors. We start from the hypothesis that the adapter molecule MyD88 may be important in the pathogenesis of PM. Thus, this project aims to study the participation of the adapter molecule MyD88 in the pathogenesis of PM, using murine models of infection. Knowledge of aspects of the innate immune response will bring an important contribution to the understanding of malaria during pregnancy, in addition to enabling new studies aimed at developing new methodologies for the treatment of PM.(AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BARBOZA, RENATO; HASENKAMP, LUTERO; BARATEIRO, ANDRE; MURILLO, OSCAR; MACHADO PEIXOTO, ERIKA PAULA; LIMA, FLAVIA AFONSO; REIS, ARAMYS SILVA; GONCALVES, LIGIA ANTUNES; EPIPHANIO, SABRINA; MARINHO, CLAUDIO R. F.. Fetal-Derived MyD88 Signaling Contributes to Poor Pregnancy Outcomes During Gestational Malaria. FRONTIERS IN MICROBIOLOGY, v. 10, . (11/17880-8, 15/10892-1, 09/53256-7, 12/14715-9, 16/07030-0, 15/06106-0, 17/03939-7, 11/19048-8, 13/16417-8, 09/53889-0)

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