Impact of a ketogenic diet in the oxidative characteristics, physical and lipid lipoproteins of children with intractable epilepsy

• Grant number: 12/03775-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: September 01, 2012
• End date: May 31, 2014
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Nágila Raquel Teixeira Damasceno
• Grantee: Patricia Azevedo de Lima
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The ketogenic diet is a nonpharmacological treatment prescribed especially for children and utilized in most specialized centers for patients with refractory epilepsy. The composition of the ketogenic diet is based on high fat, low carbohydrate, moderate protein, and production of ketone bodies is the probable mechanism involved in the control of seizures. The relationship between the treatment of a ketogenic diet and oxidative changes in characteristics, physical and lipid are not well established. Some studies show a significant increase in total cholesterol and triglycerides in children being treated with the ketogenic diet, although other studies have shown that changes in lipid profile in the long term do not appear to be significant, and the influence of these changes on coronary heart disease is not well knowledge. The studies in the last two decades has shown that in addition to changes in the lipid profile, the oxidative modification of lipoproteins is essential for the initiation and progression of atherosclerosis and the physical properties of lipoproteins also appear to be involved in this process, suggesting that the particle size lipoproteins, through the analysis of its subfractions can provide more details of cardiovascular risk. It is well evidenced in the literature that children with neurological disorders often have difficulties with feeding impacting on nutrition. Studies show a reduction in growth velocity in children with ketogenic diet, however the results regarding changes in body composition are inconclusive. Thus, this paper aim to evaluate the effects of the ketogenic diet on lipid profile, oxidative processes and physical lipoproteins involved in the pathogenesis of atherosclerosis, in addition to changes in body composition, since these are not well understood in the literature.

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARIANA BALDINI PRUDENCIO; PATRICIA DE AZEVEDO LIMA; MARIA CAMILA PRUPER DE FREITAS; FLÁVIA DE CONTI CARTOLANO; DANIELA KAWAMOTO MURAKAMI; NÁGILA RAQUEL TEIXEIRA DAMASCENO. Pirâmide alimentar cetogênica para pacientes com epilepsia refratária: da teoria à prática clínica. REVISTA DE NUTRICAO-BRAZILIAN JOURNAL OF NUTRITION, v. 30, n. 1, p. 99-108, 2017-02-00. (12/20789-5, 12/03775-0)

LIMA, PATRICIA AZEVEDO; DE BRITO SAMPAIO, LETICIA PEREIRA; TEIXEIRA DAMASCENO, NAGILA RAQUEL. Ketogenic diet in epileptic children: impact on lipoproteins and oxidative stress. NUTRITIONAL NEUROSCIENCE, v. 18, n. 8, p. 337-344, NOV 2015. (12/03775-0, 14/26094-4)

DE LIMA, PATRICIA AZEVEDO; PRUDENCIO, MARIANA BALDINI; MURAKAMI, DANIELA KAWAMOTO; DE BRITO SAMPAIO, LETICIA PEREIRA; FIGUEIREDO NETO, ANTONIO MARTINS; TEIXEIRA DAMASCENO, NAGILA RAQUEL. Effect of classic ketogenic diet treatment on lipoprotein subfractions in children and adolescents with refractory epilepsy. NUTRITION, v. 33, p. 271-277, JAN 2017. (12/03775-0, 11/13616-4, 14/26094-4, 12/20789-5)

PRUDENCIO, MARIANA BALDINI; LIMA, PATRICIA DE AZEVEDO; PRUPER DE FREITAS, MARIA CAMILA; CARTOLANO, FLAVIA DE CONTI; MURAKAMI, DANIELA KAWAMOTO; TEIXEIRA DAMASCENO, NAGILA RAQUEL. YYKetogenic food pyramid for patients with refractory epilepsy: From theory to clinical practice. REVISTA DE NUTRICAO-BRAZILIAN JOURNAL OF NUTRITION, v. 30, n. 1, p. 99-108, JAN-FEB 2017. (12/20789-5, 12/03775-0)

DE LIMA, PATRICIA AZEVEDO; DE BRITO SAMPAIO, LETICIA PEREIRA; TEIXEIRA DAMASCENO, NAGILA RAQUEL. Neurobiochemical mechanisms of a ketogenic diet in refractory epilepsy. Clinics, v. 69, n. 10, p. 699-705, 2014. (12/03775-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

LIMA, Patricia Azevedo de. Impact of the ketogenic diet on oxidative, physical and lipid characteristics of lipoproteins in children and adolescents with refractory epilepsy. 2014. Master's Dissertation - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.