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Action of melatonin on the induction of apoptosis through the silence of interleukin 17b strains in breast tumor

Grant number: 12/11660-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2012
Effective date (End): September 30, 2013
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Debora Aparecida Pires de Campos Zuccari
Grantee:Guilherme Berto Calvinho
Home Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil

Abstract

Cytokines are intercellular mediators which regulate survival, differentiation and effector functions of cells and has been proven to be related to cancer. Some of them have definite activity, but the understanding of its interaction with the genesis and tumor progression may contribute to the success of preventive and therapeutic protocols. The IL-25 is known for her role in the immune response and it is known that the interaction with its receptor IL-25R induces apoptosis. Little is known about this interaction, only that there is competition for the site of action with IL-17B in neoplastic cells, contributing to tumor progression. It has been proposed that melatonin may protect normal cells from apoptosis, and conversely, induce it in neoplastic cells. The objective of this study is to control tumor growth through increased apoptosis as a therapeutic strategy in breast neoplasms. Will be held the silencing of IL-17B associated and not associated with melatonin in human cell lines. These results could allow the use of interleukins associated or not with melatonin as therapeutic agents in breast cancer.