The role of the inflammasome in a murine model of infection with Trichophyton rubrum: activation pathways and in vivo relevance

• Grant number: 12/14684-6
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: September 01, 2012
• End date: April 30, 2016
• Field of knowledge: Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
• Principal Investigator: Sandro Rogerio de Almeida
• Grantee: Fábio Seiti Yamada Yoshikawa
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Nod-like receptor (NLR) are receptor of the innate immunity related to screening the intracellular environment, recognizing pathogen-associated molecular patterns (PAMPs) or damage to the host. Once activated, NLRs can form inflammasomes, multiprotein platforms involved in the activation of caspase-1 and, subsequently, proinflammatory cytokines IL-1² and IL-18.NLRs and Inflammasomes activities have been linked to several pathophysiological processes, such as diabetes, obesity and infectious diseases (bacterial, viral and fungal). Particularly for mycoses, literature support a significant role for the inflammasomes in the shaping of the adaptive immunity (protective responses Th1 and Th17).Trichophyton rubrum is the main agent of dermatophytosis, cutaneous mycoses that compromise keratinized tissues (skin, hair and nails). However, little is known about the immune response involved in the disease. Thus, this study aims to evaluate the participation in the pathogenesis of this infection inflamassome. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

YAMADA YOSHIKAWA, FABIO SEITI; FERREIRA, LUCAS GONCALVES; DE ALMEIDA, FERNANDO GONCALVES; DE ALMEIDA, SANDRO ROGERIO. An In Vitro Model for the Study of the Macrophage Response Upon Trichophyton rubrum Challenge. Mycopathologia, v. 182, n. 1-2, SI, p. 241-250, FEB 2017. (12/14684-6, 10/07836-9)

YAMADA YOSHIKAWA, FABIO SEITI; FERREIRA, LUCAS GONCALVES; DE ALMEIDA, FERNANDO GONCALVES; DE ALMEIDA, SANDRO ROGERIO. An In Vitro Model for the Study of the Macrophage Response Upon Trichophyton rubrum Challenge. Mycopathologia, v. 182, n. 1-2, p. 10-pg., 2017-02-01. (12/14684-6, 10/07836-9)

YAMADA YOSHIKAWA, FABIO SEITI; FERREIRA, LUCAS GONCALVES; DE ALMEIDA, SANDRO ROGERIO. IL-1 signaling inhibits Trichophyton rubrum conidia development and modulates the IL-17 response in vivo. VIRULENCE, v. 6, n. 5, p. 449-457, JUL 4 2015. (12/14684-6)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

YOSHIKAWA, Fábio Seiti Yamada. The participation of innate immunity receptors in the response to Trichophyton rubrum.. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.