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Thermal analysis study of ethinylestradiol and its application in controlled release in vitro in highly ordered mesoporous silica, SBA-15

Grant number: 12/07667-8
Support type:Scholarships in Brazil - Master
Effective date (Start): September 01, 2012
Effective date (End): November 30, 2013
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal Investigator:Lucildes Pita Mercuri
Grantee:Vania Carolina Moreira
Home Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil

Abstract

Currently, studies are done work using nanotechnology nanomaterials silicate with different molecular structures, particularly focusing on highly ordered mesoporous silicas, such as SBA-15. This silica was synthesized under acidic conditions by Joined triblock copolymer with poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) [EO20PO70EO20], and has high pore volume and surface area, and stability thermal, hydrothermal and mechanical. These characteristics make this material feasible to be used as a vehicle capable of carrying substances of different nature. The ethinyl estradiol (EE) is a bioactive estrogen, and has been used in almost all formulations contraceptive, but also as a replenisher hormone. Typically, this drug is in tablet form, should be administered daily. Based on this report, the drug release allows an increase in efficiency and improvement. Therefore the investigation of these materials has been primarily in pharmaceutical products administered via oral.This work has as main objective to study the encapsulation of ethinylestradiol in the array of ordered mesoporous silica, SBA-15, and assess their controlled release in vitro studies. (AU)