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Cholestyl ester tranfer protein (CETP) impact on differentiation, lipid storage and lipolysis is adipocytes

Grant number: 11/20136-9
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): January 01, 2012
Effective date (End): June 30, 2012
Field of knowledge:Biological Sciences - Physiology - General Physiology
Principal Investigator:Helena Coutinho Franco de Oliveira
Grantee:Helena Fonseca Raposo
Supervisor: Hei Sook Sul
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Research place: University of California, Berkeley (UC Berkeley), United States  


Obesity can be defined as a state in which excess body fat accumulated adversely affects one's health. Several evidences have suggested that proteins primarily related to lipoprotein plasma transport, such as apolipoprotein CIII and E, may significantly affect the process of body fat accumulation. CETP mediates the exchange of triglycerides for esterified cholesterol from HDL to apo B containing lipoproteins. Our group is working on the hypothesis that CETP may modulate adiposity. CETP expression reduced high fat diet induced obesity in hyperlipidemic mice and reduced adiposity in normolipidemic mice under low fat diet. CETP inhibition promoted higher adiposity in hamsters. Our results showed that CETP expression reduced adiposity without any effect on fat excretion, lipogenesis, glucose uptake and lipid retention. On the other hand, the reduced adiposity phenotype could be explained by increased lipolysis and basal metabolism in CETP mice. CETP also raised adipocytes cholesterol content, which may be implicated in the modulation of lipolysis related gene expression or protein function. In order to better comprehend the underlying mechanisms, we intend to modulate CETP expression in adipocyte cell lines that express (humans) or do not expresses (mice) CETP. The aim of the training in the Laboratory of Dr. S. Sul is to acquire the know how to study adipocytes's differentiation, and gene expression modulation in vitro and in vivo. Key words: CETP, lipolysis, adipocyte, adisposity (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DEMPERSMIER, JON; SAMBEAT, AUDREY; GULYAEVA, OLGA; PAUL, SARAH M.; HUDAK, CAROLYN S. S.; RAPOSO, HELENA F.; KWAN, HIU-YEE; KANG, CHULHO; WONG, ROGER H. F.; SUL, HEI SOOK. Cold-Inducible Zfp516 Activates UCP1 Transcription to Promote Browning of White Fat and Development of Brown Fat. MOLECULAR CELL, v. 57, n. 2, p. 235-246, . (11/20136-9)

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