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Effect of proteinase inhibitor BbCI, on membrane-bound neutrophil elastase

Grant number: 11/21070-1
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): February 01, 2012
Effective date (End): July 31, 2012
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Iolanda de Fátima Lopes Calvo Tibério
Grantee:Rafael de Almeida dos Reis
Supervisor abroad: Caroline A. Owen
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Local de pesquisa : Harvard University, Boston, United States  
Associated to the scholarship:09/15910-7 - Effect of proteinase inhibitor BbCI on elastase-induced lung injury in C57BL6 mice, BP.DR


The main theory to elucidate the parenchyma destruction of emphysema, is the imbalance between proteinases and antiproteinases. The effect of proteinase inhibitor, extracted from Brazilian plants, on elastase-induced emphysema still unknown. The aim of this project is evaluate if BbCI is able to inhibit the membrane-bound proteinases on leukocyte surface. This project complement the evaluation of the BbCI treatment on experimental emphysema, and may be relevant for new therapeutical approaches on COPD treatment. (AU)