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In vitro and in vivo safety evaluation of cosmetic formulation containing coffee oil

Grant number: 12/02569-8
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): May 31, 2012
Effective date (End): January 30, 2013
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Patrícia Maria Berardo Gonçalves Maia Campos
Grantee:Tais Aleriana Lucon Wagemaker
Supervisor: Luis António Monteiro Rodrigues
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Research place: Universidade Lusófona de Humanidades e Tecnologias, Portugal  
Associated to the scholarship:09/14031-0 - Application of coffee oil in cosmetic formulations: evaluation of stability and effectiveness of sunscreen, BP.DR


Coffee oil is a complex mixture of substances which the main components are essential fatty acids, especially linoleic acid. Therefore, this oil has been widely used as an emollient to promote skin hydration. Furthermore, according to results obtained by our research group in a pre-clinical study "in vivo", coffee oil vehiculated in cosmetic formulations showed photoprotective activity by reducing the number of sunburn cells after irradiation with ultraviolet radiation.Currently, the health regulatory agencies worldwide has prioritized the use of alternative methods to animals in studies of safety and efficacy due to the methods in such studies will be banned for cosmetic products until 2013.In this sense, the methods developed in cell culture has been used as fundamental tools for conducting research with new ingredients and cosmetic formulations to minimize cost and time by avoiding experiments with animals and obtaining data relevant to clinical studies. Thus properties of coffee oil, when it is vehiculated in high concentrations in a cosmetic formulation, could be better investigated by the application of this formulation in cell culture. Considering the above-mentioned properties of the coffee oil and the safety tests in cell culture to be an alternative method for further studies by our research group, we intend to perform experiments in Universidade Lusófona, Lisboa, Portugal to complete the experiments proposed in the PhD project for demonstrating the safety of the formulation developed and to obtain more conclusive results as well as a greater number of publications. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
WAGEMAKER, T. A. L.; RIJO, P.; RODRIGUES, L. M.; MAIA CAMPOS, P. M. B. G.; FERNANDES, A. S.; ROSADO, C.. Integrated approach in the assessment of skin compatibility of cosmetic formulations with green coffee oil. International Journal of Cosmetic Science, v. 37, n. 5, p. 506-510, . (12/02569-8, 09/14031-0)
WAGEMAKER, TAIS A. L.; MAIA CAMPOS, PATRICIA M. B. G.; FERNANDES, ANA SOFIA; RIJO, PATRICIA; NICOLAI, MARISA; ROBERTO, AMILCAR; ROSADO, CATARINA; REIS, CATARINA; RODRIGUES, LUIS M.; LIMONTA CARVALHO, CASSIA REGINA; et al. Unsaponifiable matter from oil of green coffee beans: cosmetic properties and safety evaluation. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, v. 42, n. 10, p. 1695-1699, . (12/02569-8, 09/14031-0)

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