| Grant number: | 12/05065-0 |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| Start date: | June 01, 2012 |
| End date: | August 31, 2012 |
| Field of knowledge: | Agronomical Sciences - Veterinary Medicine - Animal Pathology |
| Principal Investigator: | Debora Aparecida Pires de Campos Zuccari |
| Grantee: | Bruna Victorasso Jardim-Perassi |
| Supervisor: | Ali Syed Arbab |
| Host Institution: | Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil |
| Institution abroad: | Henry Ford Health System, United States |
| Associated to the scholarship: | 11/01054-1 - Angiogenesis evaluation in response to treatment with melatonin in breast cancer: a study in vitro and in vivo, BP.DR |
Abstract Breast cancer is the most common type of cancer in women, and the leading cause of death of patients due to tumor growth and metastasis development. The tumor growth requires the formation of new vessels which are stimulated by vascular endothelial growth factor (VEGF), expressed under the control of hypoxia-inducible factor - 1 alpha (HIF-1alpha). Thus, the VEGF and its receptors and molecules involved in angiogenesis are a prime target for new therapeutic agents. Some studies have shown that the introduction of exogenous melatonin, a hormone secreted by the pineal gland, has oncostatic effects, and may reduce angiogenesis mediated by VEGF and HIF-1± in some tumor types, although this relationship has not been described for breast cancer. Thus, the purpose of this study is to evaluate the effects of treatment with melatonin on VEGF-mediated angiogenesis in breast cancer. Breast cancer MDA-MB-231 cells will be inoculated in athymic nude mice for the development of breast cancer. The animals will be divided into two groups, one treated with melatonin and the other not. At the end of treatment, will be performed the computed tomography and single photon emission tomography (SPECT) using the agent Tc-99m-HYNIC-VEGF-C that allows the analysis of angiogenesis in animal model. The data obtained in this study may provide clues to the use of melatonin as a therapeutic agent in the treatment of breast cancer, reducing tumor growth and improving the prognosis. (AU) | |
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