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Angiogenesis evaluation in response to treatment with melatonin in breast cancer

Grant number: 12/05065-0
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): June 01, 2012
Effective date (End): August 31, 2012
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal researcher:Debora Aparecida Pires de Campos Zuccari
Grantee:Bruna Victorasso Jardim-Perassi
Supervisor abroad: Ali Syed Arbab
Home Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil
Research place: Henry Ford Health System, United States  
Associated to the scholarship:11/01054-1 - Angiogenesis evaluation in response to treatment with melatonin in breast cancer: a study in vitro and in vivo, BP.DR

Abstract

Breast cancer is the most common type of cancer in women, and the leading cause of death of patients due to tumor growth and metastasis development. The tumor growth requires the formation of new vessels which are stimulated by vascular endothelial growth factor (VEGF), expressed under the control of hypoxia-inducible factor - 1 alpha (HIF-1alpha). Thus, the VEGF and its receptors and molecules involved in angiogenesis are a prime target for new therapeutic agents. Some studies have shown that the introduction of exogenous melatonin, a hormone secreted by the pineal gland, has oncostatic effects, and may reduce angiogenesis mediated by VEGF and HIF-1± in some tumor types, although this relationship has not been described for breast cancer. Thus, the purpose of this study is to evaluate the effects of treatment with melatonin on VEGF-mediated angiogenesis in breast cancer. Breast cancer MDA-MB-231 cells will be inoculated in athymic nude mice for the development of breast cancer. The animals will be divided into two groups, one treated with melatonin and the other not. At the end of treatment, will be performed the computed tomography and single photon emission tomography (SPECT) using the agent Tc-99m-HYNIC-VEGF-C that allows the analysis of angiogenesis in animal model. The data obtained in this study may provide clues to the use of melatonin as a therapeutic agent in the treatment of breast cancer, reducing tumor growth and improving the prognosis. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
JARDIM-PERASSI, BRUNA VICTORASSO; ARBAB, ALI S.; FERREIRA, LIVIA CARVALHO; BORIN, THAIZ FERRAZ; VARMA, NADIMPALLI R. S.; ISKANDER, A. S. M.; SHANKAR, ADARSH; ALI, MESER M.; PIRES DE CAMPOS ZUCCARI, DEBORA APARECIDA. Effect of Melatonin on Tumor Growth and Angiogenesis in Xenograft Model of Breast Cancer. PLoS One, v. 9, n. 1 JAN 9 2014. Web of Science Citations: 71.

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