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Study of interaction of magnetic nanoparticles with cancer cells for application in nanomedicine

Grant number: 12/06394-8
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): July 04, 2012
Effective date (End): July 03, 2013
Field of knowledge:Physical Sciences and Mathematics - Physics
Principal Investigator:Valtencir Zucolotto
Grantee:Thiers Massami Uehara
Supervisor abroad: Ki-Bum Lee
Home Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Local de pesquisa : Rutgers The State University of New Jersey, New Brunswick, United States  
Associated to the scholarship:10/00486-2 - Study of the interaction of nanoparticles and nanotubes with cell membrane models and possible applications, BP.DR

Abstract

The development of nanoscience and nanotechnology in recent years has promoted a new frontier in the study of matter, allowing compounds known to have rediscovered their properties to be manipulated at level molecular. Thus, there are materials presenting a high relevance as the metal nanoparticles (NPs), since they are provided with mechanical and thermal properties rendering them suitable for the development and application devices, especially in the field of biotechnological, sensors and actuators magnetic. One possible approach is to use these nanocomposites in the manufacture of new intelligent materials for applications in nanomedicine. Owing to this great potential use of nanocomposites in biological systems, it is interesting to investigate how these materials interact at molecular leve in human cells, specially cancer cells. The investigation and control of behavior cell such as adhesion, proliferation and mobility are key issue to investigate in an interdisciplinary way (biology, physics, chemistry and materials engineering) the use of these nanomaterials in nanomedicine. The behavior cell is regulated by dynamic interactions at level oh the order od nanometers, with multiple microenviroments, such as solubility and interactions between cells. Currently there are works that involve the understanding of interactions with celullar microenviroments in nanobiological materials that are highly limited and have not been fully explored. Nanostructures can interact with cellular systems at level molecular with high selectivity and sensitivity. One major obstacle in studying the functions of cell behavior in microenviroments is the interface between biomolecules and cells. The aim of this project is developed methods in pattern (nanometer scale) with cancer cells to be used therapeutic agents in oncology. (AU)

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